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Article
The existence of senescent cells in conjunctival epithelium from elderly individuals
The ocular surface microenvironment changes with aging. However, it remains unclear if cellular senescence influences the ocular surface. We investigated the presence of p16INK4a-expressing senescent cells in hea...
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Article
Open AccessDifferences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells
Toll-like receptor 3 (TLR3) and interferon-beta promoter stimulator-1 (IPS-1) are associated with antiviral responses to double-stranded RNA viruses and contribute to innate immunity. We previously reported th...
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Chapter
Corneal Endothelial Cell Transfer
Today, different concepts of regenerative-medicine cell-based therapy are applied for the treatment of damaged tissue. Of those, one is the release of beneficial small molecules via the transfer of cultured ce...
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Protocol
Extra Eyelid-Derived Muscle Stem Cells
Skeletal muscle stem cells (MuSCs) have been proposed as suitable candidates for cell therapy to muscular disorders since they exhibit a good capacity for myogenic regeneration. However, for better therapeutic...
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Article
Open AccessQuiescent innate and adaptive immune responses maintain the long-term integrity of corneal endothelium reconstituted through allogeneic cell injection therapy
This study aims to clarify the immunogenicity in acquired and innate immune responses of cultured human corneal endothelial cells (hCECs) applied for cell injection therapy, a newly established modality for co...
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Article
Temperature effects on the disappearance and reappearance of corneal-endothelium primary cilia
To elucidate the specific functions of the primary cilia in corneal endothelial cells (CECs) by investigating the histological changes of corneal endothelium exposed at low temperature.
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Article
Risk factors for intraocular pressure elevation during the early period post cataract surgery
To assess the risk factors for intraocular pressure (IOP) elevation during the early period post cataract surgery.
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Article
Open AccessDistinct characteristics of central serous chorioretinopathy according to gender
To investigate the differences in clinical and genetic characteristics between males and females with central serous chorioretinopathy (CSC). Consecutive 302 patients (mean age; 56.3 ± 11.7, male/female: 249/5...
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Article
Potential participation of CTRP6, a complement regulator, in the pathology of age related macular degeneration
To investigate the localized expression of C1q/tumor necrosis factor related protein (CTRP) 6 in human age-related macular degeneration (AMD) retinal tissues.
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Article
Multicenter prospective observational study of fungal keratitis in Japan: analyses of culture-positive cases
To investigate the clinical characteristics and causative fungi in patients with fungal keratitis in Japan, and to determine factors related to the prognosis.
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Article
Multicenter prospective observational study of fungal keratitis in Japan: analyses of in vitro susceptibility tests for combinations of drugs
To determine the effects of a combination of two antifungal drugs against causative fungi of fungal keratitis in Japan.
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Article
Open AccessIntracellular pH affects mitochondrial homeostasis in cultured human corneal endothelial cells prepared for cell injection therapy
This study aimed to uncover the mechanism responsible for the clinical efficacy of cell injection therapy with fully differentiated cultured cells. Analysis of polarized expression of ion transporters on cultu...
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Article
Open AccessInvestigation of the relationship between ocular sarcoidosis and dry eye
A relationship between ocular sarcoidosis (OcSar) and dry eye (DE) has previously been reported. Here we investigated the tear function in OcSar, and the other uveitis, Vogt–Koyanagi–Harada disease (VKH), to e...
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Article
Correlation between surgical timing and postoperative ocular motility in orbital blowout fractures
The study reports the correlation between surgical timing and postoperative ocular motility in orbital blowout fractures.
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Article
A multicenter clinical trial of orthokeratology in school-aged children and adolescents in Japan
This study investigated the safety and efficacy of orthokeratology in myopic children in Japan.
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Article
Comparison of myopia progression between children wearing three types of orthokeratology lenses and children wearing single-vision spectacles
To evaluate factors related to myopia progression in children wearing either orthokeratology (OK) lenses or single-vision spectacles (SVS) for 2 years.
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Article
Open AccessSurgical outcomes of re-excimer laser phototherapeutic keratectomy (re-PTK)
To assess the surgical outcomes of re-excimer laser phototherapeutic keratectomy (re-PTK) for recurrent disease after initial PTK. Retrospective cohort study with historical comparison group. This study involv...
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Article
Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study
Atropine eye drops prevent the progression of myopia, but their use has not been tested in the Japanese schoolchildren population. Here, we evaluate the efficacy and safety of 0.01% atropine eye drops for myop...
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Article
Outcomes of combined gonioscopy-assisted transluminal trabeculotomy and goniosynechialysis in primary angle closure: a retrospective case series
To evaluate the additional intraocular pressure (IOP) lowering effect of gonioscopy-assisted transluminal trabeculotomy (GATT) to contemporary goniosynechialysis (GSL) in endeavouring to abolish subsequent occ...
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Article
Open AccessClinical study on the effect of multifocal contact lenses on myopia progression in myopia school children
The efficacy of peripheral low add multifocal soft contact lenses (SCLs) for suppressing the progression of myopia is controversial. The aim of the on-going present clinical study is to investigate whether or ...
