11 Result(s)
within
Sabino Liuni
English
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Article
Open AccessArena-Idb: a platform to build human non-coding RNA interaction networks
High throughput technologies have provided the scientific community an unprecedented opportunity for large-scale analysis of genomes. Non-coding RNAs (ncRNAs), for a long time believed to be non-functional, ar...
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Article
Open AccessTRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours
TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8...
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Article
Open AccessA fuzzy method for RNA-Seq differential expression analysis in presence of multireads
When the reads obtained from high-throughput RNA sequencing are mapped against a reference database, a significant proportion of them - known as multireads - can map to more than one reference sequence. These ...
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Chapter and Conference Paper
Managing NGS Differential Expression Uncertainty with Fuzzy Sets
High-performance Next-Generation Sequencing (NGS) has become a widely used technology to characterize case-control comparison studies for RNA transcripts, such as mRNAs and small non-coding RNAs. The first ste...
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Article
Open AccessClusterin transcript variants expression in thyroid tumor: a potential marker of malignancy?
Clusterin (CLU) is a ubiquitous multifunctional factor involved in neoplastic transformation. The CLU transcript variants and protein forms play a crucial role in balancing cells proliferation and death.
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Protocol
A Guideline for the Annotation of UTR Regulatory Elements in the UTRsite Collection
Gene expression regulatory elements are scattered in gene promoters and pre-mRNAs. In particular, RNA elements lying in untranslated regions (5′ and 3′UTRs) are poorly studied because of their peculiar feature...
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Article
Open AccessA platform independent RNA-Seq protocol for the detection of transcriptome complexity
Recent studies have demonstrated an unexpected complexity of transcription in eukaryotes. The majority of the genome is transcribed and only a little fraction of these transcripts is annotated as protein codin...
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Article
Open AccessBEAT: Bioinformatics Exon Array Tool to store, analyze and visualize Affymetrix GeneChip Human Exon Array data from disease experiments
It is known from recent studies that more than 90% of human multi-exon genes are subject to Alternative Splicing (AS), a key molecular mechanism in which multiple transcripts may be generated from a single gen...
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Article
Open Accessp53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data
The p53 gene family consists of the three genes p53, p63 and p73, which have polyhedral non-overlap** functions in pivotal cellular processes such as DNA synthesis and repair, growth arrest, apoptosis, genom...
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Article
Open AccessRegularized Least Squares Cancer Classifiers from DNA microarray data
The advent of the technology of DNA microarrays constitutes an epochal change in the classification and discovery of different types of cancer because the information provided by DNA microarrays allows an appr...
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Article
Untranslated regions of mRNAs
Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, u...
