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Article
Open AccessTRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours
TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8...
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Article
Open AccessA platform independent RNA-Seq protocol for the detection of transcriptome complexity
Recent studies have demonstrated an unexpected complexity of transcription in eukaryotes. The majority of the genome is transcribed and only a little fraction of these transcripts is annotated as protein codin...
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Article
Open AccessIdentification of tumor-associated cassette exons in human cancer through EST-based computational prediction and experimental validation
Many evidences report that alternative splicing, the mechanism which produces mRNAs and proteins with different structures and functions from the same gene, is altered in cancer cells. Thus, the identification...
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Article
Open Accessp53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data
The p53 gene family consists of the three genes p53, p63 and p73, which have polyhedral non-overlap** functions in pivotal cellular processes such as DNA synthesis and repair, growth arrest, apoptosis, genom...
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Article
Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target
The discovery of the p73 and p63 genes, homologous to p53 tumor suppressor has uncovered a family of transcription factors and widened the scenario of cell cycle control and apoptosis. We have identified a put...
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Article
Molecular characterization of p53 mutations in primary and secondary liver tumors
p53 is one of the most mutated genes in human cancer. We have performed the molecular characterization of p53 and have searched for correlations with etiological factors and clinical parameters in primary and ...
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Article
Lineage Specificity of the Evolutionary Dynamics of the mtDNA D-Loop Region in Rodents
This paper reports an intraorder study on the D-loop-containing region of the mitochondrial DNA in rodents. A complete multialignment of this region is not feasible with the exception of some conserved regions...
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Protocol
Mutation of p53 Tumor Suppressor Gene in Hepatocellular Carcinoma
In recent years, the most commonly observed genetic alteration in hepatocellular carcinoma (HCC), as in many other tumors affecting man, has been reported to be the mutation of the p53 coding gene (1,2). This gen...
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Article
The evolution of the RNase P- and RNase MRP-associated RNAs: Phylogenetic analysis and nucleotide substitution rate
We report a detailed evolutionary study of the RNase P- and RNase MRP- associated RNAs. The analyses were performed on all the available complete sequences of RNase MRP (vertebrates, yeast, plant), nuclear RNa...
