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Protocol
Accurate Analysis of Lipid Building Blocks Using the Tool LipidOne
LC/MS-based analysis techniques combined with specialized lipid platforms allow the qualitative and quantitative determination of thousands of lipid molecules. Each individual molecule can be considered as an ...
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Article
Expression and co-expression analyses of TMPRSS2, a key element in COVID-19
The ACE2 receptor is, so far, the best-known host factor for SARS-CoV-2 entry, but another essential element, the TMPRSS2 protease, has recently been identified. Here, we have analysed TMPRSS2 expression data ...
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Article
Different Cardiotoxicity of Palbociclib and Ribociclib in Breast Cancer: Gene Expression and Pharmacological Data Analyses, Biological Basis, and Therapeutic Implications
Breast cancer is the most frequent tumor in women. The recent advent of cyclin-dependent kinase (CDK) 4/6 inhibitors palbociclib and ribociclib has represented a major step forward for patients with hormone re...
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Article
Weighted gene co-expression network analysis reveals key genes involved in pancreatic ductal adenocarcinoma development
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy. Up till now, the patient’s prognosis remains poor which, among others, is due to the paucity of reliable early diagnostic biomarkers. ...
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Article
Epithelial to Mesenchymal Transition in Renal Cell Carcinoma: Implications for Cancer Therapy
Epithelial-to-mesenchymal transition (EMT) is a developmentally vital reversible process by which fully differentiated cells lose their epithelial features and acquire a migratory mesenchymal phenotype. EMT co...
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Protocol
A Guideline for the Annotation of UTR Regulatory Elements in the UTRsite Collection
Gene expression regulatory elements are scattered in gene promoters and pre-mRNAs. In particular, RNA elements lying in untranslated regions (5′ and 3′UTRs) are poorly studied because of their peculiar feature...
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Article
Open AccessHow much do we know about the coupling of G-proteins to serotonin receptors?
Serotonin receptors are G-protein-coupled receptors (GPCRs) involved in a variety of psychiatric disorders. G-proteins, heterotrimeric complexes that couple to multiple receptors, are activated when their rece...
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Article
Open AccessTRAM (Transcriptome Mapper): database-driven creation and analysis of transcriptome maps from multiple sources
Several tools have been developed to perform global gene expression profile data analysis, to search for specific chromosomal regions whose features meet defined criteria as well as to study neighbouring gene ...
