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Article
Open AccessTRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours
TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8...
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Article
Open AccessA fuzzy method for RNA-Seq differential expression analysis in presence of multireads
When the reads obtained from high-throughput RNA sequencing are mapped against a reference database, a significant proportion of them - known as multireads - can map to more than one reference sequence. These ...
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Article
Open AccessA platform independent RNA-Seq protocol for the detection of transcriptome complexity
Recent studies have demonstrated an unexpected complexity of transcription in eukaryotes. The majority of the genome is transcribed and only a little fraction of these transcripts is annotated as protein codin...
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Article
Open AccessRespiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells
Aerobic glycolysis, namely the Warburg effect, is the main hallmark of cancer cells. Mitochondrial respiratory dysfunction has been proposed to be one of the major causes for such glycolytic shift. This hypoth...
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Article
Genotype–phenotype correlation in Juvenile Paget disease: role of molecular alterations of the TNFRSF11B gene
Juvenile Paget disease (JPD) {MIM 239000} is a rare inherited bone disease that affects children. The patients affected with JPD present an altered bone turnover, therefore, show a phenotype characterized by p...
