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  1. Article

    Open Access

    Arena-Idb: a platform to build human non-coding RNA interaction networks

    High throughput technologies have provided the scientific community an unprecedented opportunity for large-scale analysis of genomes. Non-coding RNAs (ncRNAs), for a long time believed to be non-functional, ar...

    Vincenzo Bonnici, Giorgio De Caro, Giorgio Constantino, Sabino Liuni in BMC Bioinformatics (2018)

  2. Article

    Open Access

    A fuzzy method for RNA-Seq differential expression analysis in presence of multireads

    When the reads obtained from high-throughput RNA sequencing are mapped against a reference database, a significant proportion of them - known as multireads - can map to more than one reference sequence. These ...

    Arianna Consiglio, Corrado Mencar, Giorgio Grillo, Flaviana Marzano in BMC Bioinformatics (2016)

  3. No Access

    Protocol

    A Guideline for the Annotation of UTR Regulatory Elements in the UTRsite Collection

    Gene expression regulatory elements are scattered in gene promoters and pre-mRNAs. In particular, RNA elements lying in untranslated regions (5′ and 3′UTRs) are poorly studied because of their peculiar feature...

    Matteo Giulietti, Giorgio Grillo, Sabino Liuni, Graziano Pesole in RNA Bioinformatics (2015)

  4. Article

    Open Access

    A platform independent RNA-Seq protocol for the detection of transcriptome complexity

    Recent studies have demonstrated an unexpected complexity of transcription in eukaryotes. The majority of the genome is transcribed and only a little fraction of these transcripts is annotated as protein codin...

    Claudia Calabrese, Marina Mangiulli, Caterina Manzari, Anna Maria Paluscio in BMC Genomics (2013)

  5. Article

    Open Access

    BEAT: Bioinformatics Exon Array Tool to store, analyze and visualize Affymetrix GeneChip Human Exon Array data from disease experiments

    It is known from recent studies that more than 90% of human multi-exon genes are subject to Alternative Splicing (AS), a key molecular mechanism in which multiple transcripts may be generated from a single gen...

    Arianna Consiglio, Massimo Carella, Giorgio De Caro in BMC Bioinformatics (2012)

  6. Article

    Open Access

    p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data

    The p53 gene family consists of the three genes p53, p63 and p73, which have polyhedral non-overlap** functions in pivotal cellular processes such as DNA synthesis and repair, growth arrest, apoptosis, genom...

    Elisabetta Sbisà, Domenico Catalano, Giorgio Grillo, Flavio Licciulli in BMC Bioinformatics (2007)

  7. Article

    Open Access

    Regularized Least Squares Cancer Classifiers from DNA microarray data

    The advent of the technology of DNA microarrays constitutes an epochal change in the classification and discovery of different types of cancer because the information provided by DNA microarrays allows an appr...

    Nicola Ancona, Rosalia Maglietta, Annarita D'Addabbo, Sabino Liuni in BMC Bioinformatics (2005)

  8. Article

    Untranslated regions of mRNAs

    Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, u...

    Flavio Mignone, Carmela Gissi, Sabino Liuni, Graziano Pesole in Genome Biology (2002)