46 Result(s)
within
Rosalba Giugno
English
-
Article
Open AccessExposure to source-specific air pollution in residential areas and its association with dementia incidence: a cohort study in Northern Sweden
The aim of this study was to investigate the relationship between source-specific ambient particulate air pollution concentrations and the incidence of dementia. The study encompassed 70,057 participants from ...
-
Article
Open AccessB-cell receptor signaling activity identifies patients with mantle cell lymphoma at higher risk of progression
Mantle cell lymphoma (MCL) is an incurable B-cell malignancy characterized by a high clinical variability. Therefore, there is a critical need to define parameters that identify high-risk patients for aggressi...
-
Chapter
Motif Finding Algorithms: A Performance Comparison
Network motifs are subgraphs of a network that occur more frequently than expected, according to some reasonable null model. They represent building blocks of complex systems such as genetic interaction networ...
-
Article
Human genetic diversity alters off-target outcomes of therapeutic gene editing
CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat disease. However, standard computational and biochemical methods to predict off-target potential focus on reference gen...
-
Article
Open AccessMicroglial amyloid beta clearance is driven by PIEZO1 channels
Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's disease (AD), toxic amyloid beta (Aβ) accumu...
-
Article
Open AccessGRAPES-DD: exploiting decision diagrams for index-driven search in biological graph databases
Graphs are mathematical structures widely used for expressing relationships among elements when representing biomedical and biological information. On top of these representations, several analyses are perform...
-
Article
Open AccessIntracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients...
-
Chapter and Conference Paper
Centrality Speeds the Subgraph Isomorphism Search Up in Target Aware Contexts
The subgraph isomorphism (SubGI) problem is known to be a NP-Complete problem. Several methodologies use heuristic approaches to solve it, differing into the strategy to search the occurrences of a graph into ...
-
Chapter and Conference Paper
On the Simulation and Automatic Parametrization of Metabolic Networks Through Electronic Design Automation
This work presents a platform for the modelling, simulation and automatic parametrization of semi-quantitative metabolic networks. Starting from a network modelled through Petri Nets (PN) and represented in SB...
-
Article
Open AccessImmunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with an overall 5-year survival rate of less than 8%. New evidence indicates that PDAC cells release pro-inflammatory metabolites that in...
-
Article
Open AccessThe 2017 Network Tools and Applications in Biology (NETTAB) workshop: aims, topics and outcomes
The 17th International NETTAB workshop was held in Palermo, Italy, on October 16-18, 2017. The special topic for the meeting was “Methods, tools and platforms for Personalised Medicine in the Big Data Era”, bu...
-
Article
Fast Subgraph Matching Strategies Based on Pattern-Only Heuristics
Many scientific applications entail solving the subgraph isomorphism problem, i.e., given an input pattern graph, find all the subgraphs of a (usually much larger) target graph that are structurally equivalent...
-
Chapter and Conference Paper
Simple Pattern-only Heuristics Lead to Fast Subgraph Matching Strategies on Very Large Networks
A wide range of biomedical applications entails solving the subgraph isomorphism problem, i.e. finding all the possible subgraphs of a target graph that are structurally equivalent to an input pattern graph. T...
-
Chapter and Conference Paper
A Reliable Method to Remove Batch Effects Maintaining Group Differences in Lymphoma Methylation Case Study
The amount of biological data is increasing and their analysis is becoming one of the most challenging topics in the information sciences. Before starting the analysis it is important to remove unwanted variab...
-
Protocol
Construction and Analysis of miRNA Regulatory Networks
This chapter is devoted to illustrate the usage of state-of-the-art methodologies for miRNA regulatory network construction and analysis. Advantages in understanding the role of miRNAs in regulating gene expre...
-
Article
Open AccessPanDelos: a dictionary-based method for pan-genome content discovery
Pan-genome approaches afford the discovery of homology relations in a set of genomes, by determining how some gene families are distributed among a given set of genomes. The retrieval of a complete gene distri...
-
Article
Open AccessCorrection to: cuRnet: an R package for graph traversing on GPU
After publication of this supplement article [1], it was brought to our attention that reference 10 and reference 12 in the article are incorrect.
-
Article
Open AccesscuRnet: an R package for graph traversing on GPU
R has become the de-facto reference analysis environment in Bioinformatics. Plenty of tools are available as packages that extend the R functionality, and many of them target the analysis of biological network...
-
Article
Open AccessArena-Idb: a platform to build human non-coding RNA interaction networks
High throughput technologies have provided the scientific community an unprecedented opportunity for large-scale analysis of genomes. Non-coding RNAs (ncRNAs), for a long time believed to be non-functional, ar...
-
Article
Open AccessINBIA: a boosting methodology for proteomic network inference
The analysis of tissue-specific protein interaction networks and their functional enrichment in pathological and normal tissues provides insights on the etiology of diseases. The Pan-cancer proteomic project, ...
