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  1. No Access

    Article

    Human genetic diversity alters off-target outcomes of therapeutic gene editing

    CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat disease. However, standard computational and biochemical methods to predict off-target potential focus on reference gen...

    Samuele Cancellieri, **g Zeng, Linda Yingqi Lin, Manuel Tognon in Nature Genetics (2023)

  2. No Access

    Chapter and Conference Paper

    Integrating Wearable and Camera Based Monitoring in the Digital Twin for Safety Assessment in the Industry 4.0 Era

    The occurrence of human errors in work processes reduces the quality of results, increases the costs due to compensatory actions, and may have heavy repercussions on the workers’ safety. The definition of rule...

    Michele Boldo, Nicola Bombieri in Leveraging Applications of Formal Methods,… (2022)

  3. No Access

    Chapter and Conference Paper

    On the Simulation and Automatic Parametrization of Metabolic Networks Through Electronic Design Automation

    This work presents a platform for the modelling, simulation and automatic parametrization of semi-quantitative metabolic networks. Starting from a network modelled through Petri Nets (PN) and represented in SB...

    Nicola Bombieri, Antonio Mastrandrea in Computational Intelligence Methods for Bio… (2020)

  4. Chapter and Conference Paper

    Integrating Simulink, OpenVX, and ROS for Model-Based Design of Embedded Vision Applications

    OpenVX is increasingly gaining consensus as standard platform to develop portable, optimized and power-efficient embedded vision applications. Nevertheless, adopting OpenVX for rapid prototy**, early algorit...

    Stefano Aldegheri, Nicola Bombieri in VLSI-SoC: Opportunities and Challenges Bey… (2019)

  5. Article

    Open Access

    Correction to: cuRnet: an R package for graph traversing on GPU

    After publication of this supplement article [1], it was brought to our attention that reference 10 and reference 12 in the article are incorrect.

    Vincenzo Bonnici, Federico Busato, Stefano Aldegheri in BMC Bioinformatics (2018)

  6. Article

    Open Access

    cuRnet: an R package for graph traversing on GPU

    R has become the de-facto reference analysis environment in Bioinformatics. Plenty of tools are available as packages that extend the R functionality, and many of them target the analysis of biological network...

    Vincenzo Bonnici, Federico Busato, Stefano Aldegheri in BMC Bioinformatics (2018)

  7. Article

    Open Access

    Arena-Idb: a platform to build human non-coding RNA interaction networks

    High throughput technologies have provided the scientific community an unprecedented opportunity for large-scale analysis of genomes. Non-coding RNAs (ncRNAs), for a long time believed to be non-functional, ar...

    Vincenzo Bonnici, Giorgio De Caro, Giorgio Constantino, Sabino Liuni in BMC Bioinformatics (2018)

  8. Chapter and Conference Paper

    Efficient Load Balancing Techniques for Graph Traversal Applications on GPUs

    Efficiently implementing a load balancing technique in graph traversal applications for GPUs is a critical task. It is a key feature of GPU applications as it can sensibly impact on the overall application per...

    Federico Busato, Nicola Bombieri in Euro-Par 2018: Parallel Processing (2018)

  9. Chapter and Conference Paper

    Parametric Multi-step Scheme for GPU-Accelerated Graph Decomposition into Strongly Connected Components

    The problem of decomposing a directed graph into strongly connected components (SCCs) is a fundamental graph problem that is inherently present in many scientific and commercial applications. Clearly, there is...

    Stefano Aldegheri, Jiří Barnat in Euro-Par 2016: Parallel Processing Worksho… (2017)

  10. No Access

    Book

  11. No Access

    Chapter

    Introduction

    Smart Systems represent a broad class of systems defined as intelligent, miniaturized devices incorporating functionality like sensing, actuation, and control. In order to support these functions, they must in...

    Nicola Bombieri, Graziano Pravadelli in Smart Systems Integration and Simulation (2016)

  12. No Access

    Article

    Reusing RTL Assertion Checkers for Verification of SystemC TLM Models

    The recent trend towards system-level design gives rise to new challenges for reusing existing (RTL) intellectual properties (IPs) and their verification environment in (TLM). While techniques and tools to abs...

    Nicola Bombieri, Franco Fummi, Valerio Guarnieri in Journal of Electronic Testing (2015)

  13. No Access

    Chapter and Conference Paper

    Dynamic Modeling and Simulation of Leukocyte Integrin Activation through an Electronic Design Automation Framework

    Model development and analysis of biological systems is recognized as a key requirement for integrating in-vitro and in-vivo experimental data. In-silico simulations of a biochemical model allows one to test d...

    Nicola Bombieri, Rosario Distefano in Computational Methods in Systems Biology (2014)

  14. No Access

    Article

    On the Reuse of Heterogeneous IPs into SysML Models for Integration Validation

    The paper proposes an integrated methodology to abstract already existing heterogeneous IPs into SysML behavioral equivalent models. This approach aims at integrating the abstracted components with partially s...

    Nicola Bombieri, Emad Ebeid, Franco Fummi, Michele Lora in Journal of Electronic Testing (2013)

  15. No Access

    Article

    On the Reuse of TLM Mutation Analysis at RTL

    Mutation analysis has gained consensus during the last decades as being an efficient technique for measuring the quality of SW testbench. More recently, it has been efficiently applied for validating testbench...

    Valerio Guarnieri, Giuseppe Di Guglielmo, Nicola Bombieri in Journal of Electronic Testing (2012)

  16. No Access

    Article

    FAST: An RTL Fault Simulation Framework based on RTL-to-TLM Abstraction

    Functional verification techniques based on fault injection and simulation at register-transfer level (RTL) have been largely investigated in the past years. Although they have various advantages such as scala...

    Nicola Bombieri, Franco Fummi, Valerio Guarnieri in Journal of Electronic Testing (2012)

  17. No Access

    Article

    HDTLib: an efficient implementation of SystemC data types for fast simulation at different abstraction levels

    SystemC is the de-facto standard language for system-level modeling, architectural exploration, performance analysis, software development, and functional verification of embedded systems. Nevertheless, it has...

    Nicola Bombieri, Franco Fummi, Valerio Guarnieri in Design Automation for Embedded Systems (2012)

  18. Article

    Open Access

    HIFSuite: Tools for HDL Code Conversion and Manipulation

    HIFSuite ia a set of tools and application programming interfaces (APIs) that provide support for modeling and verification of HW/SW systems. The core of HIFSuite is the HDL Intermediate Format (HIF) language ...

    Nicola Bombieri, Giuseppe Di Guglielmo in EURASIP Journal on Embedded Systems (2010)

  19. No Access

    Chapter and Conference Paper

    Hardware Design and Simulation for Verification

    The development of more and more complex embedded systems constitutes a very challenging task for EDA experts, due to their HW/SW-mixed nature joint to the high demand for quality and reliability. Recently, bo...

    Nicola Bombieri, Franco Fummi in Formal Methods for Hardware Verification (2006)