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Article
Open AccessSoluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
Soluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in multiple sclerosis. In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis.
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Chapter and Conference Paper
Using Random Forest Distances for Outlier Detection
In recent years, a great variety of outlier detectors have been proposed in the literature, many of which are based on pairwise distances or derived concepts. However, in such methods, most of the efforts have...
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Chapter and Conference Paper
RF-Isolation: A Novel Representation of Structural Connectivity Networks for Multiple Sclerosis Classification
Magnetic Resonance Imaging (MRI) is one of the tools used to identify structural and functional changes caused by multiple sclerosis, and by processing MR images, connectivity networks can be obtained. The ana...
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Chapter and Conference Paper
An Alternative Exploitation of Isolation Forests for Outlier Detection
Isolation Forests are one of the most successful outlier detection techniques: they isolate outliers by performing random splits in each node. It has been recently shown that a trained Random Forest-based mode...
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Chapter and Conference Paper
A Novel Anomaly Score for Isolation Forests
Isolation Forests represent a recent variant of Random Forests, specifically designed for one-class classification problems. In the original version, this method builds a set of extremely randomized trees to d...
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Protocol
Construction and Analysis of miRNA Regulatory Networks
This chapter is devoted to illustrate the usage of state-of-the-art methodologies for miRNA regulatory network construction and analysis. Advantages in understanding the role of miRNAs in regulating gene expre...
