-
Article
The promise of a protist: the Dictyostelium genome project
The genome of Dictyostelium discoideum is being sequenced by an international consortium and is scheduled for completion in the next few years. The sequence will accelerate research into a number of phenomena ca...
-
Article
Sequence and analysis of chromosome 2 of Dictyostelium discoideum
The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despit...
-
Article
Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae
The evolution of cooperation is central to the transition by organisms from unicellular to multicellular states. Mutant cells that 'cheat' by benefiting from the cooperation of others but offering nothing in r...
-
Article
Open AccessConserved developmental transcriptomes in evolutionarily divergent species
Evolutionarily divergent organisms often share developmental anatomies despite vast differences between their genome sequences. The social amoebae Dictyostelium discoideum and Dictyostelium purpureum have similar...
-
Article
Open AccessComparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum
The social amoebae (Dictyostelia) are a diverse group of Amoebozoa that achieve multicellularity by aggregation and undergo morphogenesis into fruiting bodies with terminally differentiated spores and stalk ce...
-
Article
Open AccessMeta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors
A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections a...
