7 Result(s)
within
Christopher R. L. Thompson
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Article
Open AccessThe genetic architecture underlying prey-dependent performance in a microbial predator
Natural selection should favour generalist predators that outperform specialists across all prey types. Two genetic solutions could explain why intraspecific variation in predatory performance is, nonetheless,...
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Article
Open AccessMutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Genomes can be sequenced with relative ease, but ascribing gene function remains a major challenge. Genetically tractable model systems are crucial to meet this challenge. One powerful model is the social amoeba
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Open AccessConditional expression explains molecular evolution of social genes in a microbe
Conflict is thought to play a critical role in the evolution of social interactions by promoting diversity or driving accelerated evolution. However, despite our sophisticated understanding of how conflict sha...
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Open AccessA polychromatic ‘greenbeard’ locus determines patterns of cooperation in a social amoeba
Cheaters disrupt cooperation by rea** the benefits without paying their fair share of associated costs. Cheater impact can be diminished if cooperators display a tag (‘greenbeard’) and recognise and preferen...
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Article
Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel
Rab GTPases play key roles in the delivery, docking and fusion of intracellular vesicles. However, the mechanism by which spatial and temporal regulation of Rab GTPase activity is controlled is poorly understo...
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Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae
The evolution of cooperation is central to the transition by organisms from unicellular to multicellular states. Mutant cells that 'cheat' by benefiting from the cooperation of others but offering nothing in r...
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Article
An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum
Membrane ion channels of the P2X class, which are gated by extracellular ATP, have been thought to be an exclusivity of multicellular organisms. Now, a functional P2X receptor in the social amoeba Dictyostelium d...
