-
Article
Open AccessEndothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle
The estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells, which have the potential to ...
-
Article
Open AccessMacrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice
Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates vascular inflammation is poorly understood. Here we...
-
Article
Open AccessResveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1
Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that re...
-
Article
Open AccessGenetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice
Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis initiation and progression1. Activin A receptor-like type 1 (ACVRL1, called activin-like kinase receptor (ALK1)) is a...
-
Article
Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression
The neonatal mammalian heart is capable of regeneration for a brief window of time after birth. However, this regenerative capacity is lost within the first week of life, which coincides with a postnatal shift...
-
Article
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
Atherosclerosis, which underlies life-threatening cardiovascular disorders such as myocardial infarction and stroke1, is initiated by passage of low-density lipoprotein (LDL) cholesterol into the artery wall and ...
-
Article
Open AccessIdentifying genes with tri-modal association with survival and tumor grade in cancer patients
Previous cancer genomics studies focused on searching for novel oncogenes and tumor suppressor genes whose abundance is positively or negatively correlated with end-point observation, such as survival or tumor...
-
Article
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
During cold stimulation, cholesterol is converted to bile acids in an alternative pathway. The bile acids then alter the microbiota, which in turn promotes more heat generation.
-
Chapter
Regulation of eNOS in Caveolae
Caveolae are a specialized subset of lipid domains that are prevalent on the plasma membrane of endothelial cells. They compartmentalize signal transduction molecules which regulate multiple endothelial functi...
-
Article
Patent Ductus Arteriosus Ligation Alters Pulmonary Gene Expression in Preterm Baboons
Ibuprofen-induced ductus closure improves pulmonary mechanics and increases alveolar surface area in premature baboons compared with baboons with a persistent patent ductus arteriosus (PDA). Ibuprofen-treatmen...
-
Article
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
The cardioprotective effects of estrogen are mediated by receptors expressed in vascular cells. Here we show that 27-hydroxycholesterol (27HC), an abundant cholesterol metabolite that is elevated with hypercho...
-
Article
Inhaled Nitric Oxide: Effects on Cerebral Growth and Injury in a Baboon Model of Premature Delivery
Inhaled nitric oxide (iNO) enhances ventilation in very preterm infants, but the effects on the brain remain uncertain. We evaluated the impact of iNO on brain growth and cerebral injury in a premature baboon ...
-
Article
The Cold, Hard Truth About Pediatric Research
-
Article
Surfactant Composition and Function in a Primate Model of Infant Chronic Lung Disease: Effects of Inhaled Nitric Oxide
Bronchopulmonary dysplasia, or chronic lung disease (CLD), of premature infants involves injury from hyperoxia and mechanical ventilation to an immature lung. We examined surfactant and nitric oxide (NO), whic...
-
Chapter
Regulation of Endothelial No Synthase Activity by Estrogen Receptors in a Steroid Receptor Fast-Action Complex (SRFC) in Caveolae
The hormone estrogen has atheroprotective and vasoactive properties that are at least partially due to direct actions on the vascular endothelium. Although estrogen classically exerts its effects by modifying ...
-
Article
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
Atherosclerosis is the primary cause of cardiovascular disease, and the risk for atherosclerosis is inversely proportional to circulating levels of high-density lipoprotein (HDL) cholesterol. However, the mech...
-
Article
Maternal Vitamin A Administration and the Fetal Ductus Arteriosus: Commentary on the article by Wu et al. on page 747
-
Article
Differential Roles of Estrogen Receptors Alpha and Beta in the Nongenomic Activation of Endothelial Nitric Oxide Synthase by Estradiol
-
Article
Estrogen Acutely Activates Prostacyclin Synthesis in Ovine Fetal Pulmonary Artery Endothelial Cells
-
Article
Estrogen Receptors and eNOS are Colocalized as Components of a Signaling Module on the Plasma Membrane of Endothelial Cells
