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Article
Ibuprofen Treatment for Closure of Patent Ductus Arteriosus Is Not Associated With Increased Risk of Neuropathology
Ibuprofen is an effective pharmacological intervention for closure of a patent ductus arteriosus (PDA) in preterm infants and is an alternative to surgical ligation; however, it is not certain whether ibuprofe...
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Article
High-Frequency Oscillatory Ventilation Is Not Associated With Increased Risk of Neuropathology Compared With Positive Pressure Ventilation: A Preterm Primate Model
High-frequency oscillatory ventilation (HFOV) may improve pulmonary outcome in very preterm infants, but the effects on the brain are largely unknown. We hypothesized that early prolonged HFOV compared with lo...
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Article
Developmental and Neuropathological Consequences of Ductal Ligation in the Preterm Baboon
A patent ductus arteriosus (PDA) alters pulmonary mechanics and regional blood flow in the preterm infant. Its significance with respect to brain injury and brain development are unclear. We evaluated the effe...
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Article
Inhaled Nitric Oxide: Effects on Cerebral Growth and Injury in a Baboon Model of Premature Delivery
Inhaled nitric oxide (iNO) enhances ventilation in very preterm infants, but the effects on the brain remain uncertain. We evaluated the impact of iNO on brain growth and cerebral injury in a premature baboon ...
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Article
White Matter Injury after Repeated Endotoxin Exposure in the Preterm Ovine Fetus
Intrauterine infection has been linked to neurologic injury in preterm infants. However, a reproducible model of white matter injury in the preterm fetus in a long gestation species that can be monitored in utero
