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Article
Open AccessEndothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle
The estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells, which have the potential to ...
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Article
Open AccessMacrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice
Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates vascular inflammation is poorly understood. Here we...
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Article
Open AccessResveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1
Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that re...
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Article
Novel Functions of Endothelial Scavenger Receptor Class B Type I
Scavenger receptor class B type I (SR-BI) serves a key role in the reverse cholesterol transport in the liver as the high-affinity receptor for HDL. SR-BI is abundantly expressed in endothelium, and earlier wo...
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Article
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
Atherosclerosis, which underlies life-threatening cardiovascular disorders such as myocardial infarction and stroke1, is initiated by passage of low-density lipoprotein (LDL) cholesterol into the artery wall and ...
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Article
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
During cold stimulation, cholesterol is converted to bile acids in an alternative pathway. The bile acids then alter the microbiota, which in turn promotes more heat generation.
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Chapter
Mechanisms of Antiphospholipid Antibody-Mediated Pregnancy Morbidity
Pregnancy complications are a frequent and unsolved condition in patients with antiphospholipid syndrome (APS). Women with antiphospholipid antibodies (aPL) are at high risk of recurrent early pregnancy loss a...
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Article
Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth
Cardiovascular function depends on patent, continuous and stable blood vessel formation by endothelial cells (ECs). Blood vessel development initiates by vasculogenesis, as ECs coalesce into linear aggregates...
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Article
Inhibition of Nitric Oxide and Antiphospholipid Antibody-Mediated Thrombosis
The antiphospholipid syndrome (APS) is characterized by recurrent vascular thrombosis, thrombocytopenia, and fetal loss occurring in the presence of antiphospholipid antibodies (aPL). Along with arterial and v...
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Chapter
Regulation of eNOS in Caveolae
Caveolae are a specialized subset of lipid domains that are prevalent on the plasma membrane of endothelial cells. They compartmentalize signal transduction molecules which regulate multiple endothelial functi...
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Chapter
Regulation of Endothelial No Synthase Activity by Estrogen Receptors in a Steroid Receptor Fast-Action Complex (SRFC) in Caveolae
The hormone estrogen has atheroprotective and vasoactive properties that are at least partially due to direct actions on the vascular endothelium. Although estrogen classically exerts its effects by modifying ...
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Article
Potocytosis
Potocytosis represents a mechanism by which small and large molecules as well as macromolecular complexes are sequestered and transported by caveolae. Caveolae are flask-shaped plasma membrane specializations...
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Article
Exocrine function of caerulein-induced acute pancreatitis in anesthetized rats
Exocrine function was studied in anesthetized rats that had received two specific doses of caerulein (maximal stimulation and supramaximal stimulation). Male Wistar rats (body weight, 200–250 g) were divided i...
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Article
Intracellular action of an exogenous low-molecular-weight synthetic protease inhibitor, E3123, in cerulein-induced acute pancreatitis in rats
The intracellular distribution and action of a new synthetic protease inhibitor, E3123, were studied in cerulein-induced acute pancreatitis in rats. Acute pancreatitis was induced by a 4-h iv infusion of a sup...
