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Article
Open AccessPerinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
The hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fe...
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Article
Open AccessPerinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies
The hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional regulation, learning, memory, and cognition. Hippocampal development is exq...
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Chapter and Conference Paper
Heart Disease Link to Fetal Hypoxia and Oxidative Stress
The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of develo** disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter re...
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Article
Statins prevent adverse effects of postnatal glucocorticoid therapy on the develo** brain in rats
Postnatal glucocorticoid therapy in the treatment of chronic lung disease benefits lung function, however it adversely affects brain development. We hypothesized that combined postnatal glucocorticoid and stat...
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Article
Developmental and Neuropathological Consequences of Ductal Ligation in the Preterm Baboon
A patent ductus arteriosus (PDA) alters pulmonary mechanics and regional blood flow in the preterm infant. Its significance with respect to brain injury and brain development are unclear. We evaluated the effe...
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Article
Inhaled Nitric Oxide: Effects on Cerebral Growth and Injury in a Baboon Model of Premature Delivery
Inhaled nitric oxide (iNO) enhances ventilation in very preterm infants, but the effects on the brain remain uncertain. We evaluated the impact of iNO on brain growth and cerebral injury in a premature baboon ...
