13 Result(s)

Article

Anatomic Closure of the Premature Patent Ductus Arteriosus: The Role of CD14⁺/CD163⁺ Mononuclear Cells and VEGF in Neointimal Mound Formation

Permanent closure of the newborn ductus arteriosus requires the development of neointimal mounds to completely occlude its lumen. VEGF is required for neointimal mound formation. The size of the neointimal mou...

Nahid Waleh, Steven Seidner, Donald McCurnin, Luis Giavedoni… in Pediatric Research (2011)

Article

Patent Ductus Arteriosus Ligation Alters Pulmonary Gene Expression in Preterm Baboons

Ibuprofen-induced ductus closure improves pulmonary mechanics and increases alveolar surface area in premature baboons compared with baboons with a persistent patent ductus arteriosus (PDA). Ibuprofen-treatmen...

Nahid Waleh, Donald C McCurnin, Bradley A Yoder, Philip W Shaul… in Pediatric Research (2011)

Article

Patterns of Gene Expression in the Ductus Arteriosus Are Related to Environmental and Genetic Risk Factors for Persistent Ductus Patency

Three independent risk factors (immature gestation, absence of antenatal glucocorticoid exposure, and presence of the rs2817399(A) allele of the gene TFAP2B) are associated with patent ductus arteriosus (PDAs) th...

Nahid Waleh, Ryan Hodnick, Nami Jhaveri, Suzanne McConaghy… in Pediatric Research (2010)

Article

Chronic In Utero Cyclooxygenase Inhibition Alters PGE2-Regulated Ductus Arteriosus Contractile Pathways and Prevents Postnatal Closure

Although prostaglandin E2 (PGE2) vasodilates the ductus arteriosus, tocolysis with cyclooxygenase (COX) inhibitors delays postnatal ductus arteriosus closure. We used fetal mice and sheep to determine whether ...

Jeff Reese, Nahid Waleh, Stanley D Poole, Naoko Brown… in Pediatric Research (2009)

Article

Oxygen-Induced Tension in the Sheep Ductus Arteriosus: Effects of Gestation on Potassium and Calcium Channel Regulation

Compared with the full-term ductus arteriosus, the premature ductus is less likely to constrict when exposed to postnatal oxygen concentrations. We used isolated fetal sheep ductus arteriosus (pretreated with ...

Nahid Waleh, Jeff Reese, Hiroki Ka**o, Christine Roman… in Pediatric Research (2009)

Article

Expression, Activity, and Function of Phosphodiesterases in the Mature and Immature Ductus Arteriosus

A patent ductus arteriosus is due in large part to increased sensitivity of the premature ductus to PGE2. After PGE2 stimulation, cAMP concentrations are higher in the immature than in the mature ductus. cAMP ...

Hanguan Liu, Vincent Manganiello, Nahid Waleh, Ronald I Clyman in Pediatric Research (2008)

Article

The Role of Monocyte-Derived Cells and Inflammation in Baboon Ductus Arteriosus Remodeling

Inflammatory processes play a crucial role in the pathogenesis of atherosclerosis and other vascular disorders. We hypothesized that ischemia of the ductus arteriosus might initiate an active inflammatory resp...

Nahid Waleh, Steven Seidner, Donald McCurnin, Bradley Yoder… in Pediatric Research (2005)

Article

Effects of Hypoxia, Hypoglycemia, and Muscle Shortening on Cell Death in the Sheep Ductus Arteriosus

After birth, constriction of the full-term ductus arteriosus produces ischemic hypoxia, caspase activation, DNA fragmentation (>70% of cell nuclei are positive by the terminal deoxynucleotidyl transferase nick...

Seth Goldbarg, Timothy Quinn, Nahid Waleh, Christine Roman… in Pediatric Research (2003)

Article

The Role of Hypoxia in Ductus Closure and Reopening

Hiroki Ka**o, Yao Qi Chen, Nahid Waleh, Cameron J Koch… in Pediatric Research (1999)

Article

Permanent Anatomic Closure of the Ductus Arteriosus in Newborn Baboons: The Roles of Postnatal Constriction, Hypoxia, and Gestation

Permanent closure of the ductus arteriosus require loss of cells from the muscle media and development of neointimal mounds, composed in part of proliferating endothelial cells. We hypothesized that postnatal ...

Ronald I Clyman, Cecilia Y Chan, Françoise Mauray, Yao Qi Chen… in Pediatric Research (1999)

Article

Regulation of Ductus Arteriosus Patency by Nitric Oxide in Fetal Lambs: The Role of Gestation, Oxygen Tension, and Vasa Vasorum

We hypothesized that nitric oxide (NO) production by the fetal ductus arteriosus is limited because of low fetal PO₂, but that at neonatal PO₂, NO might be an important regulator of ductus arteriosus tone. We exp...

Ronald I Clyman, Nahid Waleh, Stephen M Black, R Kirk Riemer… in Pediatric Research (1998)

Article

Nitric Oxide (NO), Vasa Vasorum (v.v.), and the Ductus Arteriosus. • 845

Ronald I. Clyman, Nahid Waleh, Stephen Black, R. Kirk Riemer in Pediatric Research (1997)