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Article
Open AccessAuthor Correction: IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity
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Article
Open AccessIL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity
Human natural killer T cells (NKTs) are innate-like T lymphocytes increasingly used for cancer immunotherapy. Here we show that human NKTs expressing the pro-inflammatory cytokine interleukin-12 (IL-12) underg...
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Article
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to therapies1. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour microenvironment, leading to dysregulate...
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Article
Open AccessHuman T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia
Acute leukemia relapsing after chemotherapy plus allogeneic hematopoietic stem cell transplantation can be treated with donor-derived T cells, but this is hampered by the need for donor/recipient MHC-matching ...
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Article
Open AccessBone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT
The major cause of death after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for acute myeloid leukemia (AML) is disease relapse. We investigated the expression of Inhibitory Receptors (IR; PD-1/CT...
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Article
Open AccessAlliance Against Cancer, the network of Italian cancer centers bridging research and care
Alliance Against Cancer (ACC) was established in Rome in 2002 as a consortium of six Italian comprehensive cancer centers (Founders). The aims of ACC were to promote a network among Italian oncologic instituti...
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Article
Somatically mutated tumor antigens in the quest for a more efficacious patient-oriented immunotherapy of cancer
Although cancer immunotherapy shows efficacy with adoptive T cell therapy (ACT) and antibody-based immune checkpoint blockade, efficacious therapeutic vaccination of cancer patients with tumor-associated antig...
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Protocol
B Cell Helper Assays
Activation, proliferation and differentiation of naïve B lymphocytes into memory B cells and plasma cells requires engagement of the B cell receptor (BCR) coupled to T-cell help (1, 2). T cells deliver help in co...
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Article
Erratum: T cell recognition of lipids: quo vadis?
Nat. Immunol. 8, 223–227 (2007); published online 15 February 2007 In the version of this article initially published, 'Competing Interests Statement' section was missing. The section should read as follows: C...
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Article
T cell recognition of lipids: quo vadis?
The 4th International NKT Cell & CD1 Workshop was held 4–8 October 2006 at the Abbazia di Spineto, in the heart of Tuscany. This report highlights cutting-edge research and issues discussed at the meeting.
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Article
Open AccessGeneration of functional HLA-DR*1101 tetramers receptive for loading with pathogen or tumour derived synthetic peptides
MHC class I-peptide tetramers are currently utilised to characterize CD8+ T cell responses at single cell level. The generation and use of MHC class II tetramers to study antigen-specific CD4+ T cells appears les...
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Chapter
Structure of the TCR-Ag-MHC Complex
T cells recognize foreign antigen via a tri-molecular complex composed of the T cell receptor (TCR), an antigenic peptide (Ag), and a molecule encoded by the major histocompatibility complex (MHC). Much effort...
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Article
A family of trans-acting factors with distinct regulatory functions control expression of MHC class II genes
