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  1. Article

    Open Access

    Orthogonal cytokine engineering enables novel synthetic effector states esca** canonical exhaustion in tumor-rejecting CD8+ T cells

    To date, no immunotherapy approaches have managed to fully overcome T-cell exhaustion, which remains a mandatory fate for chronically activated effector cells and a major therapeutic challenge. Understanding h...

    Jesus Corria-Osorio, Santiago J. Carmona, Evangelos Stefanidis… in Nature Immunology (2023)

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  2. No Access

    Protocol

    Probing the Interactions of NK Cell Receptors with Ligand Expressed in trans and cis

    Certain receptors on natural killer (NK) cells, which are specific for MHC class I (MHC-I) molecules, do not only interact with ligand expressed on opposing cell membranes (in trans) but also interact with those ...

    Jonathan Back, Léonardo Scarpellino, Werner Held in Natural Killer Cell Protocols (2010)

  3. No Access

    Article

    Cis association of Ly49A with MHC class I restricts natural killer cell inhibition

    Natural killer (NK) cell function is negatively regulated by inhibitory receptors interacting with major histocompatibility complex class I molecules expressed on target cells. Here we show that the inhibitory...

    Marie-Agnès Doucey, Léonardo Scarpellino, Jacques Zimmer… in Nature Immunology (2004)

  4. No Access

    Article

    Nonobese diabetic and nonobese nondiabetic mice have unique MHC class II haplotypes

    Hans Acha-Orbea, Léonardo Scarpellino in Immunogenetics (1991)

  5. No Access

    Article

    A family of trans-acting factors with distinct regulatory functions control expression of MHC class II genes

    Roberto S. Accolla, Paolo Dellabona, Leonardo Scarpellino… in Immunologic Research (1990)