-
Article
Open AccessDendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings. However, the impact of cross-presenting cDC1 and the pot...
-
Article
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to therapies1. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour microenvironment, leading to dysregulate...
-
Article
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress
Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally diverse; however, the extent and determinants of neutrophil heterogeneity in humans remain unclear. We performed a compreh...
-
Article
Open AccessTIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses
Acquisition of cell-associated tumor antigens by type 1 dendritic cells (cDC1) is essential to induce and sustain tumor specific CD8+ T cells via cross-presentation. Here we show that capture and engulfment of ce...
-
Article
Open AccessACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
Atypical chemokine receptors (ACKRs) are regulators of leukocyte traffic, inflammation, and immunity. ACKR2 is a scavenger for most inflammatory CC chemokines and is a negative regulator of inflammation. Here ...
-
Protocol
Cancer and Chemokines
Chemokines are a large family of secreted cytokines whose main function is to mediate leukocyte directional migration. Most cancers contain chemokines and express chemokine receptors as a consequence of the ac...
