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Article
Effects of topoisomerase 2 inhibitors on the MLL gene in children receiving chemotherapy: a prospective study
The molecular effects of etoposide in haemopoietic cells suggest that mixed lineage leukaemia (MLL) abnormalities can be biomarkers of patient susceptibility to the genotoxic effects of topoisomerase 2 (topo 2) i...
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Article
Open AccessCoexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed lineage leukaemia (MLL) rearrangement. By molecular t...
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Article
Ponte di Legno Working Group: statement on the right of children with leukemia to have full access to essential treatment and report on the Sixth International Childhood Acute Lymphoblastic Leukemia Workshop
The Sixth International Childhood ALL Workshop was made possible by unrestricted educational grants from Sanofi-Synethelabo Inc., Glaxosmithkline, Enzon Inc., and Ilex. Preparation of the Meeting Report was su...
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Article
Open AccessVitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study
The relationship between neonatal vitamin K received by the intramuscular (i.m.) route and the development of leukaemia or other cancers was investigated as part of a national case–control study of childhood c...
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Article
Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements
To assess the clinical heterogeneity among patients with acute lymphoblastic leukemia (ALL) and various 11q23 abnormalities, we analyzed data on 497 infants, children and young adults treated between 1983 and ...
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Article
Open AccessAn infectious aetiology for childhood brain tumours? Evidence from space–time clustering and seasonality analyses
To investigate whether infections or other environmental exposures may be involved in the aetiology of childhood central nervous system tumours, we have analysed for space–time clustering and seasonality using...
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Article
Open AccessImproved outcome in children with advanced stage B-cell non-Hodgkin's lymphoma (B-NHL): results of the United Kingdom Children Cancer Study Group (UKCCSG) 9002 protocol
From July 1990 to March 1996, 112 children with stage III or IV B-cell non-Hodgkin's lymphoma (B-NHL) with up to 70% FAB L3-type blasts (n= 42) in the bone marrow without central nervous system (CNS) disease were...
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Article
Open AccessSpace–time clustering patterns in childhood leukaemia support a role for infection
Previous studies of space–time clustering in childhood leukaemia have produced equivocal and inconsistent results. To address this issue we have used Manchester Children’s Tumour Registry leukaemia data in spa...
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Article
Open AccessReduced bone mineral density in young adults following cure of acute lympblastic leukaemia in childhood
Bone mineral density (BMD), serum osteocalcin and type I collagen C-telopeptide (ICTP) were assessed in a cohort of 31 (16 males) adults who had received cranial irradiation in childhood as part of their treat...
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Article
Hyperviscosity in HIV infected children — a potential hazard during intravenous immunoglobulin therapy
A four year old boy with symptoms of HIV infection and serum IgG of 53.2 g/l had been treated for 16 months with regular infusions of intravenous immunoglobulin (IV IgG). During one such infusion he developed ...
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Chapter and Conference Paper
Medical Research Council Childhood Leukaemia Trial VIII Compared with Trials II–VII: Lessons for Future Management
Over the last 15 years, the Working Party on Childhood Leukaemia of the Medical Research Council (MRC) has conducted a series of therapeutic trials on acute lymphoblastic leukaemia (ALL). The broad principles,...
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Article
A phase II study of ifosfamide in children with recurrent solid tumours
Twenty children with recurrent or unresponsive tumours (10 Wilms', 3 rhabdomyosarcoma, 4 Ewings's, 1 osteosarcoma, 1 hepatoblastoma, 1 hepatoma) and one untreated patient with renal carcinoma were given ifosfa...
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Article
Adjuvant low dose radiation in childhood non-Hodgkin's lymphoma (report from the United Kingdom Childrens' Cancer Study Group--UKCCSG)
From July 1977 to July 1983, 120 children with non-Hodgkin's Lymphoma entered a randomised trial of combination chemotherapy and radiotherapy. The primary site was abdominal in 42 patients, mediastinal in 27 a...
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Article
Nuclear terminal deoxynucleotidyl transferase in leukaemic infiltrates of testicular tissue
Early detection of testicular leukaemia and the identification of residual leukaemic cells in treated patients are important aims in the management of males with acute lymphoblastic leukaemia (ALL). In most ca...
