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Article
Open AccessThe effect of cigarette smoking use and cessation on serum insulin-like growth factors
The patterns of risk association between circulating levels of insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, differ between smoking and nonsmoking-related cancers. To investigate t...
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Article
Open AccessElevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer
This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key clinicopathological parameters in 92 patients with color...
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Article
Open AccessFatigue, sexual function and mood following treatment for haematological malignancy: the impact of mild Leydig cell dysfunction
Fatigue, sexual dysfunction, anxiety and depression are all more common in patients who have previously been treated with cytotoxic chemotherapy and radiotherapy (XRT) for haematological malignancies. Followin...
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Article
Open AccessReduced bone mineral density in young adults following cure of acute lympblastic leukaemia in childhood
Bone mineral density (BMD), serum osteocalcin and type I collagen C-telopeptide (ICTP) were assessed in a cohort of 31 (16 males) adults who had received cranial irradiation in childhood as part of their treat...
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Article
CRANIAL IRRADIATION AND EARLY PUBERTY
Low doses of cranial irradiation (1800-2400 cGy) employed in the management of acute lymphoblastic leukaemia may cause early or precocious puberty in girls but not boys. To determine if this sexual dichotomy e...
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Article
WEIGHT GAIN FOLLOWING PROLONGED REMISSION IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKAEMIA
There is a clinical impression that patients who have heen successfully treated for acute lymphoblastic leukaemia(ALL) become obese young adults. A retrospective analysis of the medical records of 130 patients...
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Article
FINAL HEIGHT AND DISPROPORTION AFFER CRANIAL RADIOTHERAPY FOR LEUKAEMIA
Final height and skeletal proportions were studied in 142 children treated for ALL with cranial irradiation and combination chemotherapy but not spinal irradiation. Cranial irradiation consisted of 21-25 Gy in...
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Article
PROSPECTIVE RANDOMISED STUDY OF THE EFFECTS OF TREATMENT WITH EITHER LOW DOSE OXANDROLONE OR TESTOSTERONE OR PLACEBO ON THE PITUITARY-TESTICULAR AXIS IN BOYS WITH CDGP
16 boys with CDGP in early puberty (mean(S.D)age 14.2(0.7) years, bone age 11.1(0.9) years, teeticular volume 4-6 mis) were randomly assigned to treatment for 3 months with placebo (group 1, n=5), oxandrolone ...
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Article
GONADALFUNCTION AFTER FRACTIONATED TOTAL BODY IRRADIATION (TBI)
Gonadal function was assessed in 28 children (12 male) treated with fractionated TBI (1200-1440 cGy) after conditioning cytotoxic chemotherapy (cyclophosphamide [n=26] or melphalan [n = 2]). All had received p...
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Article
ENDOCRINE OUTCOME
Dependent on site and size, pituitary hormone deficits may be associated with space-occupying lesions in the pituitary and suprasellar regions (craniopharyngyoma, adenoma and germinoma). Medical awareness of s...
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Chapter
Tumours of the Endocrine Glands
The clinical presentation of a child with an endocrine tumour may be caused by the effects of a mass lesion, a hormone excess state or hormone deficiencies. Medical awareness of a hormone deficiency tends to l...
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Article
Final height in girls with untreated constitutional delay in growth and puberty
During a 10-year period, 23 girls compared to 118 boys presented with constitutional delay in growth and puberty. Of these girls, 15 were followed to final height to determine the outcome of the untreated cond...
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Chapter and Conference Paper
Gonadal Function Following Radiation and Cytotoxic Chemotherapy in Childhood
The early studies of gonadal function following cytotoxic chemotherapy were performed in patients treated for nephrotic syndrome with immunosuppressive regimens containing cyclophosphamide (Fairley et al. 1972...
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Article
Growth response to growth hormone therapy following cranial irradiation
The growth response to growth hormone (GH) therapy has been studied in 12 children who received irradiation to the cranium alone either for brain gliomas, distant from the hypothalamic-pituitary axis, or as pr...
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Article
Growth response to growth hormone therapy following craniospinal irradiation
Nineteen (12 male, 7 female) children, who have received craniospinal irradiation for the treatment of a brain tumour distant from the hypothalamic-pituitary axis, resulting in growth hormone (GH) deficiency (...
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Article
LOW DOSE OXANDROL ONE THERAPY IN CONSTITUTIONALLY DELAYED GROWTH
27 boys (aged 7.6-16yrs) with delayed growth were subdivided by testicular size into prepubertal (<4mls) and pubertal (≥4mls). 13 received 2.5mg/d oxandrolone (Ox) for 3 months, and 14 acted as controls. Each ...
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Article
FINAL STATURE AFTER GROWTH HORMONE (GH) THERAPY IN RADIATION-INDUCED GH DEFICIENCY
31 children, rendered GH deficient, by cranial (C, n=12) or craniospinal (CS, n=19) irradiation, received GH, and their growth response was compared to that of 14 GH treated idiopathic GH deficient patients (I...
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Article
HEAD GROWTH AND GROWTH HORMONE (GH) THERAPY FOLLOWING CRANIAL IRRADIATION
The occipito-frontal circumferences (OFC) of children, GH beficient following cranial irradiation, have been assessed before (n=38) and on completion of GH (n=15) or after a similar period of pbservation witho...
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Article
GONADAL DYSFUNCTION AFTER NITROSOUREA CHEMOTHERAPY (CIX) FOR CHILDHOOD BRAIN TUMOURS
We have shown that chemotherapy with nitrosoureas and not spinal irradiation is responsible for gonadal damage in our children treated for medulloblastoma (Ahmed et al, 1983). But the incidence and influence o...
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Article
The Role of Growth Hormone in Stunted Head Growth after Cranial Irradiation
ABSTRACT. The head sizes of 38 patients, growth hormone (GH) deficient following craniospinal (n=26) or cranial irradiation (n = 12), have been assessed before (n = 38) and on completion of GH therapy (n = 15) or...
