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  1. No Access

    Chapter

    Therapeutic Antibodies to Microorganisms

    Immunoglobulin preparations against microorganisms are used currently for the prevention and treatment of a wide variety of infections. Initially, intramuscular immunoglobulin (IM IgG) preparations were given,...

    P. L. Yap in Therapeutic Antibodies (1995)

  2. No Access

    Chapter and Conference Paper

    Derivation of a Rational Nomenclature for Hepatitis C Virus by Phylogenetic Analysis of the NS-5 Region

    Different isolates of hepatitis C virus (HCV) are highly polymorphic throughout the genome. Phylogenetic analysis of nucleotide sequences derived from part of the gene encoding a nonstructural protein (NS-5) h...

    E. C. Holmes, Dr. P. Simmonds, T.-A. Cha, S.-W. Chan… in Viral Hepatitis and Liver Disease (1994)

  3. No Access

    Chapter and Conference Paper

    Hepatitis C Virus Genotypes: An Investigation of Type-specific Differences in Geographic Origin and Disease

    It has become important to clarify whether distinct genotypes of the hepatitis C virus (HCV) vary with respect to pathogenicity, infectivity, response to antiviral therapy, and geographic clustering. We have a...

    Dr. G. M. Dusheiko, H. Schmilovitz-Weiss, D. Brown… in Viral Hepatitis and Liver Disease (1994)

  4. No Access

    Chapter

    Humoral Functions of Immunoglobulin: Relationship to Purification Technology of Intravenous Immunoglobulin

    One of the major therapeutic achievements in the field of clinical immunology in the last twenty years has been the development of safe and effective immunoglobulin of therapeutic applications in immunodeficie...

    P. L. Yap in Immunology and Blood Transfusion (1993)

  5. No Access

    Article

    Hyperviscosity in HIV infected children — a potential hazard during intravenous immunoglobulin therapy

    A four year old boy with symptoms of HIV infection and serum IgG of 53.2 g/l had been treated for 16 months with regular infusions of intravenous immunoglobulin (IV IgG). During one such infusion he developed ...

    R. A. Hague, O. B. Eden, P. L. Yap, J. Y. Q. Mok, P. Rae in Blut (1990)

  6. No Access

    Article

    IgG Replacement therapy for primary hypogammaglobulinaemia during pregnancy: Report of 9 pregnancies in 4 patients

    We report the cases of four pregnant women with primary hypogammaglobulinaemia, who received intramuscular, intravenous or no replacement therapy with IgG in late pregnancy, and review the literature. Intraven...

    P. E. Williams, C. L. S. Leen, A. D. Heppleston, P. L. Yap in Blut (1990)

  7. No Access

    Article

    Post-transfusion purpura following open heart surgery: management by high dose intravenous immunoglobulin infusion

    We present three cases of post-transfusion purpura (PTP) develo** in the immediate post operative period after open heart surgery. All had developed platelet specific antibodies and severe anaphylactoid reac...

    W. S. Walker, P. L. Yap, D. C. Kilpatrick, F. E. Boulton, R. J. Crawford… in Blut (1988)