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Article
Ancient DNA confirmation of lepromatous leprosy in a skeleton with concurrent osteosarcoma, excavated from the leprosarium of St. Mary Magdalen in Winchester, Hants., UK
To establish a biological profile and disease aetiologies for one of four burials recovered during a Time Team dig at the St. Mary Magdalen leprosarium, Winchester, UK in AD 2000. Osteological techniques were app...
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Article
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains une...
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Article
Open AccessHLA-DPβ1 Asp84-Lys69 antigen-binding signature predicts event-free survival in childhood B-cell precursor acute lymphoblastic leukaemia: results from the MRC UKALL XI childhood ALL trial
We previously reported that children in the UKALL XI ALL trial with HLA-DP 1 and -DP 3 supertypes had significantly worse event-free survival (EFS) than children with other DP supertypes. As DP 1 and DP 3 shar...
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Article
Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601
We previously reported that susceptibility to childhood B cell precursor ALL (BCP ALL) is associated with HLA-DPB1 alleles having glutamic acid (E) rather than lysine (K) in the P4 antigenic peptide-binding pocke...
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Article
Open AccessHLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes
Childhood B-cell precursor (BCP) ALL is thought to be caused by a delayed immune response to an unidentified postnatal infection. An association between BCP ALL and HLA class II (DR, DQ, DP) alleles could provide...
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Article
Open AccessNew germline mutations in the hypervariable minisatellite CEB1 in the parents of children with leukaemia
Gardner and co-workers advanced the hypothesis that the Seascale leukaemia cluster could have been caused by new mutations in germ cells, induced by paternal preconceptional irradiation (PPI) exposure at the S...
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Article
Effects of topoisomerase 2 inhibitors on the MLL gene in children receiving chemotherapy: a prospective study
The molecular effects of etoposide in haemopoietic cells suggest that mixed lineage leukaemia (MLL) abnormalities can be biomarkers of patient susceptibility to the genotoxic effects of topoisomerase 2 (topo 2) i...
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Article
Open AccessCoexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed lineage leukaemia (MLL) rearrangement. By molecular t...
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Article
Open AccessAn infectious aetiology for childhood brain tumours? Evidence from space–time clustering and seasonality analyses
To investigate whether infections or other environmental exposures may be involved in the aetiology of childhood central nervous system tumours, we have analysed for space–time clustering and seasonality using...
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Article
Open AccessSpace–time clustering patterns in childhood leukaemia support a role for infection
Previous studies of space–time clustering in childhood leukaemia have produced equivocal and inconsistent results. To address this issue we have used Manchester Children’s Tumour Registry leukaemia data in spa...
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Article
Open AccessRisk factors for Hodgkin’s disease by Epstein-Barr virus (EBV) status: prior infection by EBV and other agents
A UK population-based case–control study of Hodgkin’s disease (HD) in young adults (16–24 years) included 118 cases and 237 controls matched on year of birth, gender and county of residence. The majority (103)...
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Article
Open AccessFurther investigation of the role of HLA-DPB1 in adult Hodgkin’s disease (HD) suggests an influence on susceptibility to different HD subtypes
It has been suggested in a number of studies that susceptibility to adult Hodgkin’s disease (HD) is influenced by the HLA class II region, and specifically by alleles at the HLA-DPB1 locus. Since HD is diagnostic...
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Article
A role for glucagon-like peptide-1 in the central regulation of feeding
THE sequence of glucagon-like peptide-1 (7–36) amide (GLP-1) is completely conserved in all mammalian species studied, implying that it plays a critical physiological role1. We have shown that GLP-1 and its speci...
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Article
Analysis of gene-dosage effects on the expression of CD18 by trisomy 21 lymphoblastoid cell-lines using a statistical model to fit flow cytometry profiles
It is not clear whether Down syndrome, the phenotypic expression of constitutional trisomy for chromosome 21 (T21), is the result of generalised disruption of homeostasis resulting from genetic imbalance, or t...
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Chapter
Inactive renin and the vasculature
Whilst the vasculature is normally considered as a target organ for the circulating renin-angiotensin system, there is growing evidence that the enzyme cascade also exists in blood vessels in man, and that the...
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Article
Non-HLA Antigens in Health, Aging and Malignancy. Progress in Clinical and Biological Research
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Article
Lack of correlation between lymphocyte activating determinants and HLA-DR on acute leukaemias
The expression of allogenic lymphocyte-activating determinants (LAD) on 25 acute leukaemias has been compared with the expression of cell-surface antigens identified by HLA-DR allo- and xeno-antisera. The clos...
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Article
An HLA-DR negative acute leukaemia which stimulates MLC and CMC responses
We describe an acute myelomonocytic leukaemia (E72) devoid of cell-surface HLA-DR antigens, but capable of inducing cellular responses. Leukaemia E72 induced proliferation of normal lymphocytes in primary mixe...
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Article
The role of allogeneic cells in the stimulation of cell-mediated cytotoxicity to leukaemia cells
Allogeneic lymphocytes can stimulate cell-mediated cytotoxicity (CMC) in lymphocytes from leukaemia patients against autologous leukaemia target cells. We have compared the capacity of different allogeneic lym...
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Article
Susceptibility of human leukaemias to cell-mediated cytotoxicity by interferon-treated allogeneic lymphocytes
Twenty-two human leukaemias, comprising acute phase leucocytes from 13 acute myeloid and nine lymphoid leukaemias, were tested for susceptibility to spontaneous cell-mediated cytotoxicity (CMC) by untreated ly...
