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Article
Left Ventricular Diastolic Filling Patterns Associated with Progressive Anthracycline-Induced Myocardial Damage: A Prospective Study
The objective of this study was to examine changes in diastolic function associated with progressive myocardial damage and their implications. We used prospective sequential Doppler echocardiographic studies ...
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Article
National Scientific Medical Meeting 1994 Abstracts
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Article
Rhabdomyosarcoma associated with familial adenomatous polyposis
We report a case of a 16 year old girl with orbital rhabdomyosarcoma who during chemotherapy developed bloody diarrhoea. On investigation she was found to have multiple colonic polyps. Cytogenetic analysis has...
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Article
Bacteraemia related to indwelling central venous catheters: Prevention, diagnosis and treatment
Infective episodes in immunocompromised children with indwelling central venous catheters were studied prospectively for one year. Culture of catheter hubs and skin at catheter entry sites during the first six...
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Article
Burkitt-like lymphoma in an English child: Characterisation of tumour biopsy cells and of the derived tumour cell line
An eight year old English boy presented with an abdominal undifferentiated 'Burkitt-like' lymphoma. Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short ...
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Article
The growth of children following cranial irradiation
Children who have required cranial irradiation for malignant disease may become growth hormone (GH) deficient. We have reviewed the records of 37 children to determine whether their height velocity in the firs...
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Article
Adjuvant low dose radiation in childhood T cell leukaemia/lymphoma (report from the United Kingdom Childrens' Cancer Study Group--UKCCSG)
From November 1977 to July 1983, 82 children with T leukaemia/lymphoma entered a randomised trial of combination chemotherapy and radiotherapy. Twenty-five were designated T lymphoma and 57 T leukaemia, 28 hav...
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Article
Adjuvant low dose radiation in childhood non-Hodgkin's lymphoma (report from the United Kingdom Childrens' Cancer Study Group--UKCCSG)
From July 1977 to July 1983, 120 children with non-Hodgkin's Lymphoma entered a randomised trial of combination chemotherapy and radiotherapy. The primary site was abdominal in 42 patients, mediastinal in 27 a...
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Chapter
Malignant Disease in Childhood
Cancer in childhood is fortunately rare, with an approximate annual incidence of 100 cases per million children in the developed world. It is, nevertheless, the commonest disease to kill children in our societ...
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Article
Tumours of the head and neck in children—clinicopathologic perspectives
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Article
Pancreatic Tumours in Children—Cancer Treatments and Research
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Chapter
Neurotoxic Complications of CNS prophylaxis in Childhood Leukaemia
There is general agreement that the biggest single advance in the treatment of childhood leukaemia in the last fifteen years has been the introduction of effective CNS prophylaxis against meningeal relapse, us...
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Chapter
The Childhood Lymphomas
The leukaemias and lymphomas of childhood account for almost half of the malignant disease seen in this age group in the Western world. The lymphomas represent 10% of the total, with an approximately even divi...
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Article
Unpredictable serum levels after oral methotrexate in children with acute lymphoblastic leukaemia
Serum methotrexate levels were measured for 5 h after oral intake in 11 children with acute lymphoblastic leukaemia. The curves obtained with the child's regular dose of methotrexate varied widely, and were in...
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Chapter
Growth and Hormonal Status after Treatment of Childhood Acute Lymphoblastic Leukaemia
As increasing numbers of children complete the long and intensive treatment for acute lymphoblastic leukaemia (ALL) we become more keenly aware of the quality of their long-term survival. The future potential ...
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Chapter
CT Brain Scans after CNS Prophylaxis for Acute Lymphoblastic Leukaemia
The introduction of prophylactic treatment of the central nervous system in children with acute lymphoblastic leukaemia has been the biggest single factor in increasing their survival in the last 15 years. The...