31 Result(s)

Article

Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains

Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantation in host brains under continuous immunosuppressive admin...

Su Feng, Ting Zhang, Zhengxiao He, Wenchang Zhang, Yingying Chen… in Cell Regeneration (2024)

Article

Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation

Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages ...

Ran Wang, **anfa Yang, Jiehui Chen, Lin Zhang… in Nature Communications (2023)

Article

Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation

During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in this field, the functional significance of DNA methylation in e...

Qing Li, Jiansen Lu, **di Yin, Yunjian Chang, Chao Wang, Meng Yan… in Nature Communications (2023)

Article

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI). These disorders are current...

He Jax Xu, Yao Yao, Fenyong Yao, Jiehui Chen, Meishi Li, **anfa Yang… in Cell Regeneration (2023)

Article

The therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder associated with aging. Due to its insidious onset, protracted progression, and unclear pathogenesis, it is considered one of the most obs...

Chunmei Yue, Su Feng, Yingying Chen, Naihe **g in Cell Regeneration (2022)

Article

Author Correction: Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

**aoxiao Wang, Yunlong **ang, Yang Yu, Ran Wang, Yu Zhang, Qianhua Xu… in Cell Research (2022)

Article

Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively. However, these two states of pluripotenc...

**aoxiao Wang, Yunlong **ang, Yang Yu, Ran Wang, Yu Zhang, Qianhua Xu… in Cell Research (2021)

Article

Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Guangdun Peng, Shengbao Suo, Guizhong Cui, Fang Yu, Ran Wang, Jun Chen… in Nature (2020)

Article

Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies

Social hierarchies emerged during evolution, and social rank influences behavior and health of individuals. However, the evolutionary mechanisms of social hierarchy are still unknown in amniotes. Here we devel...

Yuting Wang, Guangyi Dai, Zhili Gu, Guopeng Liu, Ke Tang, Yi-Hsuan Pan… in Cell Research (2020)

Article

Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo

An Amendment to this paper has been published and can be accessed via a link at the top of the paper.

Guangdun Peng, Shengbao Suo, Guizhong Cui, Fang Yu, Ran Wang, Jun Chen… in Nature (2020)

Article

A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. A...

Yifei Zhou, Xueqing Wang, Mengjiao Song, Zhidong He, Guizhong Cui… in Nature Communications (2019)

Article

Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14

RNA-binding proteins with intrinsically disordered regions (IDRs) such as Rbm14 can phase separate in vitro. To what extent the phase separation contributes to their physiological functions is however unclear....

Yue **ao, Jiehui Chen, Yihan Wan, Qi Gao, Naihe **g, Yixian Zheng… in Cell Discovery (2019)

Article

Author Correction: Hormones induce the formation of luminal-derived basal cells in the mammary gland

In the initial published version of this article, there was a mistake in one author name (**gsong Li). The correct name should be “**song Li”. This correction does not affect the description of the results o...

Wenqian Song, Ran Wang, Weimin Jiang, Qi Yin, Guangdun Peng, Ruikai Yang… in Cell Research (2019)

Article

Author Correction: Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

In the version of this article initially published, the following grant numbers and recipients were missing from the Acknowledgements: XDB19000000 to H.J. and B.Z.; 81430066 and 31621003 to H.J.; 2017YFA050550...

Qiaozhen Liu, Kuo Liu, Guizhong Cui, **uzhen Huang, Shun Yao, Wenke Guo… in Nature Genetics (2019)

Article

Author Correction: Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

In the version of this Article originally published, the first name of author Guangdun Peng was spelled incorrectly as Guangdum. This has now been amended in all versions of the Article.

Neophytos Christodoulou, Christos Kyprianou, Antonia Weberling… in Nature Cell Biology (2018)

Article

Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

In the version of this Technical Report originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions...

Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na… in Nature Cell Biology (2018)

Article

Author Correction: Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Su Feng, Can **ng, Tingyu Shen, Yunbo Qiao, Ran Wang, Jun Chen… in Scientific Reports (2018)

Article

Inference of differentiation time for single cell transcriptomes using cell population reference data

Single-cell RNA sequencing (scRNA-seq) is a powerful method for dissecting intercellular heterogeneity during development. Conventional trajectory analysis provides only a pseudotime of development, and often ...

Na Sun, **aoming Yu, Fang Li, Denghui Liu, Shengbao Suo… in Nature Communications (2017)

Article

Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII

The paraventricular nucleus of hypothalamus plays important roles in the regulation of energy balance and fetal growth. However, the molecular mechanisms underlying its formation and function have not been cle...

Su Feng, Can **ng, Tingyu Shen, Yunbo Qiao, Ran Wang, Jun Chen… in Scientific Reports (2017)

Article

CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development

Studying the early function of essential genes is an important and challenging problem in developmental biology. Here, we established a method for rapidly inducing CRISPR-Cas9-mediated mutations in one blastom...

Lingbo Wang, Min-Yin Li, Chao Qu, Wan-Ying Miao, Qi Yin, Jiaoyang Liao… in Cell Research (2017)