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  1. No Access

    Article

    An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer

    Poor-prognosis oestrogen receptor-positive breast cancer is characterised by the presence of high-level focal amplifications. We utilised a focused small interfering RNA screen in 14 breast cancer cell lines t...

    I Garcia-Murillas, R Sharpe, A Pearson, J Campbell, R Natrajan, A Ashworth… in Oncogene (2014)

  2. No Access

    Article

    Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies

    Overexpression of the receptor tyrosine kinase ERBB2 (also known as HER2) occurs in around 15% of breast cancers and is driven by amplification of the ERBB2 gene. ERBB2 amplification is a marker of poor prognosis...

    K-K Shiu, D Wetterskog, A Mackay, R Natrajan, M Lambros, D Sims, I Bajrami… in Oncogene (2014)

  3. No Access

    Article

    Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

    Triple negative breast cancers (TNBCs) have a relatively poor prognosis and cannot be effectively treated with current targeted therapies. We searched for genes that have the potential to be therapeutic target...

    N Turner, M B Lambros, H M Horlings, A Pearson, R Sharpe, R Natrajan, F C Geyer… in Oncogene (2010)