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  1. Article

    Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

    While it is well known that diet-induced obesity causes insulin resistance, the precise mechanisms underpinning the initiation of insulin resistance are unclear. To determine factors that may cause insulin res...

    N. Turner, G. M. Kowalski, S. J. Leslie, S. Risis, C. Yang, R. S. Lee-Young… in Diabetologia (2013)

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  2. Article

    AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle

    We determined whether: (1) an acute lipid infusion impairs skeletal muscle AMP-activated protein kinase (AMPK)α2 activity, increases inducible nitric oxide synthase (iNOS) and causes peripheral insulin resista...

    R. S. Lee-Young, J. S. Bonner, W. H. Mayes, I. Iwueke, B. A. Barrick… in Diabetologia (2013)

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    Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKα2 in the regulation of exercise capacity in vivo

    Skeletal muscle AMP-activated protein kinase (AMPK)α2 activity is impaired in obese, insulin-resistant individuals during exercise. We determined whether this defect contributes to the metabolic dysregulation ...

    R S Lee-Young, J E Ayala, P T Fueger, W H Mayes, L Kang… in International Journal of Obesity (2011)

  4. Article

    Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice

    Toll-like receptor 4 (TLR4) is a receptor for saturated fatty acids (SFAs), global deficiency of which has been shown to protect against inflammation, insulin resistance and atherosclerotic lesion formation. B...

    K. R. Coenen, M. L. Gruen, R. S. Lee-Young, M. J. Puglisi, D. H. Wasserman… in Diabetologia (2009)

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