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Article
Correction: The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression
A Correction to this paper has been published: https://doi.org/10.1038/s41388-020-01535-1
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Article
Open AccessThe transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression
The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway. In melanoma, such ...
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Article
Open AccessElucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells
Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach. Here, we compared the mode of action of romidepsi...
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Article
Open AccessBRAF inhibition causes resilience of melanoma cell lines by inducing the secretion of FGF1
Approximately half of all melanoma patients harbour activating mutations in the serine/threonine kinase BRAF. This is the basis for one of the main treatment strategies for this tumor type, the targeted therap...
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Article
Open AccessCutaneous CD8+ Cytotoxic T-Cell Lymphoma Infiltrates: Clinicopathological Correlation and Outcome of 35 Cases
Cytotoxic CD8+ T-cell lymphomas are only rarely encountered and thus remain only poorly characterized. Our aim was to collect and correlate clinical and histological data of CD8+ skin lymphoma infiltrates to o...
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Article
Open AccessSurvivin-specific T-cell reactivity correlates with tumor response and patient survival: a phase-II peptide vaccination trial in metastatic melanoma
Therapeutic vaccination directed to induce an anti-tumoral T-cell response is a field of extensive investigation in the treatment of melanoma. However, many vaccination trials in melanoma failed to demonstrate...
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Article
Open AccessThe concept of "compartment allergy": prilocaine injected into different skin layers
We herein present a patient with delayed-type allergic hypersensitivity against prilocaine leading to spreading eczematous dermatitis after subcutaneous injections for local anesthesia with prilocaine. Priloca...
