59 Result(s)

Article

Dermatologist-like explainable AI enhances trust and confidence in diagnosing melanoma

Artificial intelligence (AI) systems have been shown to help dermatologists diagnose melanoma more accurately, however they lack transparency, hindering user acceptance. Explainable AI (XAI) methods can help t...

Tirtha Chanda, Katja Hauser, Sarah Hobelsberger… in Nature Communications (2024)

Article

Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates...

Markus Haake, Beatrice Haack, Tina Schäfer, Patrick N. Harter… in Nature Communications (2023)

Article

Severe and Prolonged Liver Damage in Pityriasis Rubra Pilaris Treated with acitretin: a Case Report

Acitretin is a systemic retinoid that is used in dermatology for treatment of various inflammatory and especially hyperkeratotic diseases. Elevation of liver enzymes may occur occasionally but normally resolve...

Katrin Rak, Henning Hamm, Andreas Kerstan… in SN Comprehensive Clinical Medicine (2022)

Article

Translational development of ABCB5⁺ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers

While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured ski...

Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth… in Stem Cell Research & Therapy (2022)

Article

Activity of ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy with poor prognosis. In Europe, approved systemic therapies are limited to the PD-L1 inhibitor avelumab. For avelumab-re...

Valerie Glutsch, Hermann Kneitz, Anja Gesierich… in Cancer Immunology, Immunotherapy (2021)

Article

Patterns of care and follow-up care of patients with uveal melanoma in German-speaking countries: a multinational survey of the German Dermatologic Cooperative Oncology Group (DeCOG)

Uveal melanoma (UM) is an orphan cancer of high unmet medical need. Current patterns of care and surveillance remain unclear as they are situated in an interdisciplinary setting.

Theresa Steeb, Anja Wessely, Mareike Alter… in Journal of Cancer Research and Clinical On… (2021)

Article

Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans

Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic ba...

Christian Schwarm, Damian Gola, Maike M. Holtsche… in Orphanet Journal of Rare Diseases (2021)

Article

Dermpath & Clinic: Where the shoe pinches — painful plantar plaque

Verena G. Frings, Matthias Goebeler, Hermann Kneitz in European Journal of Dermatology (2020)