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Kutane Lymphome

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DGIM Innere Medizin

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Zusammenfassung

Hautlymphome umfassen ein breites Spektrum an prognostisch unterschiedlichen Subtypen, wobei T-Zell-Lymphome die häufigste Untergruppe darstellen. Für die endgültige Diagnosestellung ist eine sorgfältige klinisch-pathologische Korrelation entscheidend. Das häufigste Hautlymphom stellt die Mycosis fungoides dar, welche in Abhängigkeit des Krankheitsstadiums durch Patches, Plaques, Tumoren oder eine universelle Rötung des Hautorgans (= Erythrodermie) gekennzeichnet ist. Während in frühen Stadien bei der Mycosis fungoides meist hautgerichtete Therapiemaßnahmen ausreichen, sind in fortgeschrittenen Stadien und beim Sézary-Syndrom Systemtherapien oder multimodale und interdisziplinäre Therapiekonzepte indiziert. Zu den kutanen T-Zell-Lymphomen zählen des Weiteren indolente Subtypen mit meist solitärer Hautmanifestation wie die CD4-positive Lymphoproliferation oder das akrale CD8-positive Lymphom, zum anderen jedoch auch seltene aggressive Entitäten wie das periphere T-Zell-Lymphom oder das aggressive epidermotrope T-Zell-Lymphom. Kutane B-Zell-Lymphome sind selten. Während die Lebenserwartung beim kutanen Marginalzonenlymphom und kutanen follikulären B-Zell-Lymphom – trotz häufig kutaner Rezidive im Krankheitsverlauf – nahezu unbeeinträchtigt ist, zeigt das kutane großzellige B-Zell-Lymphom ein aggressives biologisches Verhalten.

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Abbreviations

R-CHOP:

Rituximab, Cyclophosphamid, Doxorubicin, Vincristin, Predniso(lo)n

WHO:

World Health Organization

EORTC:

European Organization for Research and Treatment of Cancer

CLA:

kutanes Lymphozytenantigen

CCR4:

C-C-Chemokinrezeptor Typ 4

NFkB:

nuclear factor kappa B

JAK:

Januskinase

STAT:

signal transducers and activators of transcription

MAPK:

mitogen-activated protein kinase

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Authors and Affiliations

  1. Universitätshautklinik Würzburg, Würzburg, Deutschland

    Marion Wobser

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  1. Marion Wobser
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Editors and Affiliations

  1. Universität Salzburg, Salzburg, Österreich

    Hendrik Lehnert

  2. Innere Medizin IV, Helios Dr. Horst Schmidt Kliniken Wiesba, Wiesbaden, Deutschland

    Elisabeth Märker-Hermann

  3. Medizinische Klinik I, Universitätsklinikum Aachen, RWTH Aache, Aachen, Nordrhein-Westfalen, Deutschland

    Nikolaus Marx

  4. Institut für Endokrinologie & Diabetes, Universität zu Lübeck, Lübeck, Deutschland

    Sebastian M. Meyhöfer

Section Editor information

  1. TU Dresden Universitätsklinikum Carl Gustav Carus, Dresden, Deutschland

    Sebastian M. Schellong

  2. FB Gastroenterologie und Hepatologie, Universitätsklinikum Leipzig Medizinische Klinik und Poliklinik II, Leipzig, Sachsen, Deutschland

    Joachim Mössner

  3. Krankenhaus Barmherzige Brüder, Regensburg, Deutschland

    Cornel C. Sieber

  4. Nürnberg, Bayern, Deutschland

    Walter Swoboda

  5. Universitätsklinikum Giessen und Marburg Klinik für Innere Medizin, Marburg, Hessen, Deutschland

    Andreas Neubauer

  6. Interdisziplinärer Schwerpunkt für Hämos, Universitätsklinikum Gießen und Marburg, Gießen, Deutschland

    Bettina Kemkes-Matthes

  7. Klinik für Gastroenterologie,Hepatologie, Medizinische Hochschule Hannover, Hannover, Deutschland

    Michael P. Manns

  8. Sektion für Molekulare und Klinische Inf, Universitätsklinikum Schleswig-Holstein,, Lübeck, Deutschland

    Jan Rupp

  9. Abt. Kardiologie und Pneumologie, Universitätsklinikum Göttingen Herzzentrum Göttingen, Göttingen, Deutschland

    Gerd Hasenfuß

  10. Abt. Nephrologie und Klinische Immunologie, Univ.Klinikum Aachen Medizinische Klinik II, Aachen, Deutschland

    J. Floege

  11. Universitätsklinikum Köln Klinik I für Innere Medizin, Köln, Deutschland

    Michael Hallek

  12. Klinik für Pneumologie, Medizinische Hochschule Hannover (MHH) Zentrum Innere Medizin, Hannover, Deutschland

    Tobias Welte

  13. Klinik u. Poliklinik für Innere Medizin, Universitätsmedizin Greifswald, Greifswald, Deutschland

    Markus Lerch

  14. Dr.-Horst-Schmidt-Kliniken GmbH, Wiesbaden, Deutschland

    Elisabeth Märker-Hermann

  15. Klinische Toxikologie, Giftinformation, Universitätsklinikum Mainz II. Medizinische Klinik und Poliklinik, Mainz, Deutschland

    Ludwig Sacha Weilemann

  16. Klinik für Hämatologie und Onkologie, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland

    Nikolas von Bubnoff

  17. Klinik für Hämatologie und Onkologie, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland

    Kim Luley

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Wobser, M. (2023). Kutane Lymphome. In: Lehnert, H., Märker-Hermann, E., Marx, N., Meyhöfer, S.M. (eds) DGIM Innere Medizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54676-1_514-2

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  1. Latest

    Kutane Lymphome
    Published:
    19 April 2023

    DOI: https://doi.org/10.1007/978-3-642-54676-1_514-2

  2. Original

    Primär kutane Lymphome
    Published:
    06 June 2015

    DOI: https://doi.org/10.1007/978-3-642-54676-1_514-1

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