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Article
Open AccessValidation of a German version of the Cerebellar Cognitive Affective/ Schmahmann Syndrome Scale: preliminary version and study protocol
Traditionally, cerebellar disorders including ataxias have been associated with deficits in motor control and motor learning. Since the 1980’s growing evidence has emerged that cerebellar diseases also impede ...
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Article
Extinction and Renewal of Conditioned Eyeblink Responses in Focal Cerebellar Disease
Extinction of conditioned aversive responses (CR) has been shown to be context-dependent. The hippocampus and prefrontal cortex are of particular importance. The cerebellum may contribute to context-related pr...
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ReHabX: Personalisierte Therapiesteuerung bei Gangstörungen am Beispiel des Schlaganfalls
Die Wiedergewinnung und der Erhalt der Mobilität stellen aufgrund der demografischen Entwicklung eine wachsende medizinische und soziale Problematik dar, deren Meisterung neue, moderne Lösungsstrategien aus de...
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Article
Structural correlates of motor adaptation deficits in patients with acute focal lesions of the cerebellum
Studies of cerebellar patients employing modern lesion-symptom map** techniques have provided valuable insights into the contribution of the cerebellum to motor adaptation. In patients with chronic focal les...
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Article
CCSVI and MS: a statement from the European Society of neurosonology and cerebral hemodynamics
To systematically review the ultrasonographic criteria proposed for the diagnosis of chronic cerebrospinal venous insufficiency (CCSVI). The authors analyzed the five ultrasonographic criteria, four extracrani...
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Article
Open AccessMicroalbuminuria indicates long-term vascular risk in patients after acute stroke undergoing in-patient rehabilitation
Patients in neurologic in-patient rehabilitation are at risk of cardio- and cerebrovascular events. Microalbuminuria (MAU) is frequent and an important risk predictor but has not been validated in in-patient r...
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Article
Lesion patterns in successful and failed thrombolysis in middle cerebral artery stroke
Thrombolysis has been shown to improve neurological recovery in acute stroke. But the response to thrombolysis is variable across patients. We sought to investigate this variability by analyzing the lesion pat...
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Article
Open AccessNiche-dependent development of functional neuronal networks from embryonic stem cell-derived neural populations
The present work was performed to investigate the ability of two different embryonic stem (ES) cell-derived neural precursor populations to generate functional neuronal networks in vitro. The first ES cell-derive...
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Article
Transient reduction of spontaneous neuronal network activity by sublethal amyloid β (1–42) peptide concentrations
Soluble amyloid β1–42 (Aβ1–42) peptide has recently been assigned a key role in early Alzheimer’s disease (AD) pathophysiology accounting for synaptic dysfunction before amyloid plaque formation and neurodegenera...
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Article
Aldolase C/Zebrin II is Released to the Extracellular Space after Stroke and Inhibits the Network Activity of Cortical Neurons
Cell death after stroke involves apoptotic, autophagocytic and necrotic mechanisms which may cause the release of cytosolic proteins to the extracellular space. Aldolase C (AldC) is the brain specific isoform ...
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Article
Disturbance of Cultured Rat Neuronal Network Activity Depends on Concentration and Ratio of Leucine and α-Ketoisocaproate: Implication for Acute Encephalopathy of Maple Syrup Urine Disease
Increased concentrations of leucine and its respective ketoacid α-ketoisocaproate (KIC) in plasma and cerebrospinal fluid are related to acute and reversible encephalopathy in patients with maple syrup urine d...
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Article
Immunological Aspects of Ischaemic Stroke
There is increasing evidence that inflammatory processes play a central role in atherosclerosis and in secondary infarct growth after focal cerebral ischaemia. Focal cerebral ischaemia is often the result of a...
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Article
Cooperative effects of neuronal ensembles
Electrophysiological properties of neurons as the basic cellular elements of the central nervous system and their synaptic connections are well characterized down to a molecular level. However, the behavior of...
