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Article
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy
Hepatic encephalopathy (HE) is a common neurological manifestation of liver cirrhosis and is characterized by an increase of ammonia in the brain accompanied by a disrupted neurotransmitter balance, including ...
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Article
Open Accesscalf – Software for CEST Analysis with Lorentzian Fitting
Analysis of chemical exchange saturation transfer (CEST) MRI data requires sophisticated methods to obtain reliable results about metabolites in the tissue under study. CEST generates z-spectra with multiple c...
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Article
Open AccessFeasibility of quantitative susceptibility map** (QSM) of the human kidney
To evaluate the feasibility of in-vivo quantitative susceptibility map** (QSM) of the human kidney.
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Article
Sodium MRI of human articular cartilage of the wrist: a feasibility study on a clinical 3T MRI scanner
To measure sodium relaxation times and concentrations in human wrists on a clinical magnetic resonance imaging (MRI) scanner with a density-adapted radial sequence.
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Article
Open AccessDetection of early cartilage degeneration in the tibiotalar joint using 3 T gagCEST imaging: a feasibility study
To establish and optimize a stable 3 Tesla (T) glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging protocol for assessing the articular cartilage of the tibiotalar joint in healthy volunt...
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Article
MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy
• Molecular intervertebral disc damage was associated with LBP and radiculopathy.
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Article
Open AccessDifferential effects of D-cycloserine and amantadine on motor behavior and D2/3 receptor binding in the nigrostriatal and mesolimbic system of the adult rat
D-cycloserine (DCS) and amantadine (AMA) act as partial NMDA receptor (R) agonist and antagonist, respectively. In the present study, we compared the effects of DCS and AMA on dopamine D2/3R binding in the brain ...
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Article
Comparison of B0 versus B0 and B1 field inhomogeneity correction for glycosaminoglycan chemical exchange saturation transfer imaging
The study compares glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging of intervertebral discs corrected for solely B0 inhomogeneities or both B0 and B1 inhomogeneities.
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Article
Functional MRI in transplanted kidneys
Renal transplantation is the therapy of choice for patients with end-stage renal diseases. Improvement of immunosuppressive therapy has significantly increased the half-life of renal allografts over the past d...
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Article
Quantitative pulsed CEST-MRI at a clinical 3T MRI system
The goal of this study was to quantify CEST related parameters such as chemical exchange rate and fractional concentration of exchanging protons at a clinical 3T scanner. For this purpose, two CEST quantificat...
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Article
Covert hepatic encephalopathy: elevated total glutathione and absence of brain water content changes
Recent pathophysiological models suggest that oxidative stress and hyperammonemia lead to a mild brain oedema in hepatic encephalopathy (HE). Glutathione (GSx) is a major cellular antioxidant and known to be i...
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Article
Biochemical imaging of cervical intervertebral discs with glycosaminoglycan chemical exchange saturation transfer magnetic resonance imaging: feasibility and initial results
To evaluate glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging at 3T in the assessment of the GAG content of cervical IVDs in healthy volunteers.
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Article
Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes
The pathogenesis of hepatic encephalopathy (HE) is not fully understood yet. Hyperammonemia due to liver failure and subsequent disturbance of cerebral osmolytic balance is thought to play a pivotal role in th...
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Article
Improvement of gagCEST imaging in the human lumbar intervertebral disc by motion correction
To investigate whether motion correction improves glycosaminoglycan chemical exchange saturation transfer imaging (gagCEST imaging) of intervertebral discs (IVDs).
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Article
Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner
The objective of this study was to show the feasibility to perform Iopamidol-based pH imaging via clinical 3T magnetic resonance imaging (MRI) using chemical exchange saturation transfer (CEST) imaging with pu...
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Article
Open AccessAbsolute GABA spectroscopy with MEGA-PRESS and watermap** in sensorimotor and visual cortex and correlation to handedness
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Article
T2* map** and delayed gadolinium-enhanced magnetic resonance imaging in cartilage (dGEMRIC) of glenohumeral cartilage in asymptomatic volunteers at 3 T
To establish baseline T2* and T1Gd values of glenohumeral cartilage at 3 T.
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Article
Cartilage quality in rheumatoid arthritis: comparison of T2* map**, native T1 map**, dGEMRIC, ΔR1 and value of pre-contrast imaging
To prospectively evaluate four non-invasive markers of cartilage quality—T2* map**, native T1 map**, dGEMRIC and ΔR1—in healthy volunteers and rheumatoid arthritis (RA) patients.
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Article
Hybrid 18F-FDG PET–MRI of the hand in rheumatoid arthritis: initial results
18F-fluorodeoxyglucose PET (18F-FDG PET) is highly sensitive to inflammatory changes within the synovial tissue in rheumatoid arthritis (RA). However, the highest spatial resolution for soft tissue can be achi...
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Article
Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results
To quantify renal allograft perfusion in recipients with stable allograft function and acute decrease in allograft function using nonenhanced flow-sensitive alternating inversion recovery (FAIR)-TrueFISP arter...
