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Article
Open AccessDifferential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function
Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such as bipolar disorder and major depressive disorder. Lithium salts cross the blood-brain...
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Article
Open AccessPartial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission
Alzheimer’s disease (AD) is the most common form of age-related neurodegenerative diseases. Cerebral deposition of Aβ peptides, especially Aβ42, is considered the major neuropathological hallmark of AD and the...
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Article
Open AccessStructural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug
As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-relat...
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Article
Open AccessIn vitro neuronal network activity in NMDA receptor encephalitis
Anti-NMDA-encephalitis is caused by antibodies against the N-methyl-D-aspartate receptor (NMDAR) and characterized by a severe encephalopathy with psychosis, epileptic seizures and autonomic disturbances. It p...
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Article
Open AccessA new role for interferon gamma in neural stem/precursor cell dysregulation
The identification of factors that compromise neurogenesis is aimed at improving stem cell-based approaches in the field of regenerative medicine. Interferon gamma (IFNγ) is a main pro-inflammatory cytokine an...
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Article
Open AccessProtein tyrosine phosphatases expression during development of mouse superior colliculus
Protein tyrosine phosphatases (PTPs) are key regulators of different processes during development of the central nervous system. However, expression patterns and potential roles of PTPs in the develo** super...
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Article
Open AccessNiche-dependent development of functional neuronal networks from embryonic stem cell-derived neural populations
The present work was performed to investigate the ability of two different embryonic stem (ES) cell-derived neural precursor populations to generate functional neuronal networks in vitro. The first ES cell-derive...
