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Article
Open AccessOral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial
Candida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.
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Article
Open AccessThe effects of goal-directed fluid therapy based on dynamic parameters on post-surgical outcome: a meta-analysis of randomized controlled trials
Dynamic predictors of fluid responsiveness, namely systolic pressure variation, pulse pressure variation, stroke volume variation and pleth variability index have been shown to be useful to identify in advance...
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Article
Open AccessHemodynamic goal-directed therapy and postoperative kidney injury: an updated meta-analysis with trial sequential analysis
Perioperative goal-directed therapy (GDT) reduces the risk of renal injury. However, several questions remain unanswered, such as target, kind of patients and surgery, and role of fluids and inotropes. We ther...
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Article
Open AccessVasopressor-Sparing Action of Methylene Blue in Severe Sepsis and Shock: A Narrative Review
Shock is a serious acute circulatory failure leading to inadequate oxygen delivery to the cells. Its treatment is mainly based on circulating fluid optimization, and vasopressors to provide an adequate mean ar...
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Article
Open AccessTriple Intrathecal Combination Therapy for End-Stage Cancer-Related Refractory Pain: A Prospective Observational Study with Two-Month Follow-Up
In cancer-related pain refractory to systemic opioids, intrathecal (IT) administration of morphine can be a useful strategy. In clinical practice, IT morphine is usually combined with other drugs with differen...
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Article
Open AccessA Bilateral Lumbar Multidermatomal Herpes Zoster in an Elderly Woman with Chronic Kidney Disease
Herpes zoster (HZ) is a painful rash caused by the reactivation of the varicella-zoster virus (VZV) permanently latent within the cranial or dorsal root ganglia. Usually the rash presents in only one side of t...
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Article
Open AccessAn Ensemble of Psychological and Physical Health Indices Discriminates Between Individuals with Chronic Pain and Healthy Controls with High Reliability: A Machine Learning Study
Chronic pain (CP) is a complex multidimensional experience severely affecting individuals’ quality of life. Multiple cognitive, affective, emotional, and interpersonal factors play a major role in CP. Furtherm...
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Article
Open AccessThe Routes of Administration for Acute Postoperative Pain Medication
Effective treatment of postoperative acute pain, together with early mobilization and nutrition, is one of the perioperative strategies advocated to improve surgical outcome and reduce the costs of hospitaliza...
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Article
Open AccessPerioperative goal-directed therapy and postoperative complications in different kind of surgical procedures: an updated meta-analysis
Goal-directed therapy (GDT) aims to assure tissue perfusion, by optimizing doses and timing of fluids, inotropes, and vasopressors, through monitoring of cardiac output and other basic hemodynamic parameters. ...
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Article
Open AccessLow Back Pain and Radiofrequency Denervation of Facet Joint: Beyond Pain Control—A Video Recording
Chronic low back pain is often due to L5S1 instability resulting in facet joint syndrome. Patients suffering from low back pain may also have a gait pattern characterized by a reduced speed and a shorter, asym...
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Open AccessGut Microbiota Modulation and Its Implications on Neuropathic Pain: A Comprehensive Literature Review
Neuropathic pain (NP) is a chronic pain disorder arising from somatosensory nervous system impairment. Extensive evidence supports the notion that the gut microbiota (GM) is crucial in maintaining human health...
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Open AccessMicrobial Symphony: Exploring the Role of the Gut in Osteoarthritis-Related Pain. A Narrative Review
One of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality of life by degenerating articular cartilage, modifying subchondral bone, and infl...
