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Open AccessManagement of intra-abdominal infections: recommendations by the Italian council for the optimization of antimicrobial use
Intra-abdominal infections (IAIs) are common surgical emergencies and are an important cause of morbidity and mortality in hospital settings, particularly if poorly managed. The cornerstones of effective IAIs ...
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Open AccessImmune disturbance leads to pulmonary embolism in COVID-19 more than classical risk factors: a clinical and histological study
COVID-19 induces endotheliitis and one of the main complications is enhanced coagulation. The incidence of pulmonary embolism (PE) in COVID-19 (CPE) has increased and clinical features for a rigorous analysis ...
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Article
Open AccessSubclinical cardiac dysfunction may impact on fluid and vasopressor administration during early resuscitation of septic shock
According to the Surviving Sepsis Campaign (SSC) fluids and vasopressors are the mainstays of early resuscitation of septic shock while inotropes are indicated in case of tissue hypoperfusion refractory to flu...
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Article
Open AccessCefiderocol Versus Colistin for the Treatment of Carbapenem-Resistant Acinetobacter baumannii Complex Bloodstream Infections: A Retrospective, Propensity-Score Adjusted, Monocentric Cohort Study
Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are associated with high mortality with limited treatment. The aim of this study is to compare effectiveness and safety o...
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Correction to: Use of low-molecular weight heparin, transfusion and mortality in COVID-19 patients not requiring ventilation
A correction to this paper has been published: https://doi.org/10.1007/s11239-021-02460-0
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Use of low-molecular weight heparin, transfusion and mortality in COVID-19 patients not requiring ventilation
It is still debated whether prophylactic doses of low-molecular- weight heparin (LMWH) are always effective in preventing Venous Thromboembolism (VTE) and mortality in COVID-19. Furthermore, there is paucity o...
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Open AccessTriple Intrathecal Combination Therapy for End-Stage Cancer-Related Refractory Pain: A Prospective Observational Study with Two-Month Follow-Up
In cancer-related pain refractory to systemic opioids, intrathecal (IT) administration of morphine can be a useful strategy. In clinical practice, IT morphine is usually combined with other drugs with differen...
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Open AccessContinuous assessment of neuro-ventilatory drive during 12 h of pressure support ventilation in critically ill patients
Pressure support ventilation (PSV) should allow spontaneous breathing with a “normal” neuro-ventilatory drive. Low neuro-ventilatory drive puts the patient at risk of diaphragmatic atrophy while high neuro-ven...
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Open AccessHemodynamic goal-directed therapy and postoperative kidney injury: an updated meta-analysis with trial sequential analysis
Perioperative goal-directed therapy (GDT) reduces the risk of renal injury. However, several questions remain unanswered, such as target, kind of patients and surgery, and role of fluids and inotropes. We ther...
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Article
Fusariosis in a Patient with Acute Myeloid Leukemia: A Case Report and Review of the Literature
Fusarium spp. causes infections mostly in patients with prolonged neutropenia. We describe the case of a disseminated Fusarium solani infection in a patient with ...
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Open AccessCost of care and antibiotic prescribing attitudes for community-acquired complicated intra-abdominal infections in Italy: a retrospective study
Complicated intra-abdominal infections (cIAIs) are a common cause of morbidity worldwide, and in spite of improvements in patient care, therapeutic failure still occurs, impacting in-hospital resource consumpt...
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Open AccessRapid and sensitive detection of bla KPC gene in clinical isolates of Klebsiella pneumoniae by a molecular real-time assay
The aim of this study was the rapid identification of bla KPC gene in 38 Klebsiella pneumoniae clinical isolates with reduced susceptibility to carbapenems. The modified Hodge Test (MHT) was carried out to phenot...
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Open AccessOral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial
Candida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.
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Open AccessHaemodynamic goal-directed therapy and postoperative infections: earlier is better. a systematic review and meta-analysis
Infectious complications are the main causes of postoperative morbidity. The early timing of their promoting factors is the rationale for perioperative strategies attempting to reduce them. Our aim was to dete...
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Intra-abdominal hypertensionand acute renal failurein critically ill patients
To investigate the relationship between intra-abdominal hypertension (IAH) and acute renal failure (ARF) in critically ill patients.
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Jaundice in critical illness: promoting factors of a concealed reality
In critical illness, liver dysfunction (LD) is associated with a poor outcome independently of other organ dysfunctions. Since strategies to support liver function are not available, a timely and accurate iden...
