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  1. Article

    Open Access

    Microbial Symphony: Exploring the Role of the Gut in Osteoarthritis-Related Pain. A Narrative Review

    One of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality of life by degenerating articular cartilage, modifying subchondral bone, and infl...

    Alberto Corriero, Mariateresa Giglio, Rossana Soloperto in Pain and Therapy (2024)

  2. Article

    Open Access

    Gut Microbiota Modulation and Its Implications on Neuropathic Pain: A Comprehensive Literature Review

    Neuropathic pain (NP) is a chronic pain disorder arising from somatosensory nervous system impairment. Extensive evidence supports the notion that the gut microbiota (GM) is crucial in maintaining human health...

    Alberto Corriero, Mariateresa Giglio, Francesco Inchingolo in Pain and Therapy (2024)

  3. Article

    Open Access

    Low Back Pain and Radiofrequency Denervation of Facet Joint: Beyond Pain Control—A Video Recording

    Chronic low back pain is often due to L5S1 instability resulting in facet joint syndrome. Patients suffering from low back pain may also have a gait pattern characterized by a reduced speed and a shorter, asym...

    Mariateresa Giglio, Giacomo Farì, Angela Preziosa, Alberto Corriero in Pain and Therapy (2023)

  4. Article

    Open Access

    The central role of the gut in intensive care

    Critically ill patients undergo early impairment of their gut microbiota (GM) due to routine antibiotic therapies and other environmental factors leading to intestinal dysbiosis. The GM establishes connections...

    Alberto Corriero, Raffaella Maria Gadaleta, Filomena Puntillo in Critical Care (2022)

  5. Article

    Open Access

    Perioperative goal-directed therapy and postoperative complications in different kind of surgical procedures: an updated meta-analysis

    Goal-directed therapy (GDT) aims to assure tissue perfusion, by optimizing doses and timing of fluids, inotropes, and vasopressors, through monitoring of cardiac output and other basic hemodynamic parameters. ...

    Mariateresa Giglio, Giandomenico Biancofiore in Journal of Anesthesia, Analgesia and Criti… (2021)

  6. Article

    Open Access

    The Routes of Administration for Acute Postoperative Pain Medication

    Effective treatment of postoperative acute pain, together with early mobilization and nutrition, is one of the perioperative strategies advocated to improve surgical outcome and reduce the costs of hospitaliza...

    Filomena Puntillo, Mariateresa Giglio, Giustino Varrassi in Pain and Therapy (2021)

  7. Article

    Open Access

    Cerebrospinal Fluid and Clinical Profiles in Adult Type 2–3 Spinal Muscular Atrophy Patients Treated with Nusinersen: An 18-Month Single-Centre Experience

    Nusinersen was approved as the first disease-modifying therapy in spinal muscular atrophy (SMA). Our aim was to analyse therapy-related changes in cerebrospinal fluid (CSF) and serum parameters of adult type 2...

    Giammarco Milella, Alessandro Introna, Eustachio D’Errico in Clinical Drug Investigation (2021)

  8. Article

    Open Access

    Personalizing Cancer Pain Therapy: Insights from the Rational Use of Analgesics (RUA) Group

    A previous Delphi survey from the Rational Use of Analgesics (RUA) project involving Italian palliative care specialists revealed some discrepancies between current guidelines and clinical practice with a lack...

    Giustino Varrassi, Flaminia Coluzzi, Vittorio A. Guardamagna in Pain and Therapy (2021)

  9. Article

    Open Access

    Triple Intrathecal Combination Therapy for End-Stage Cancer-Related Refractory Pain: A Prospective Observational Study with Two-Month Follow-Up

    In cancer-related pain refractory to systemic opioids, intrathecal (IT) administration of morphine can be a useful strategy. In clinical practice, IT morphine is usually combined with other drugs with differen...

    Filomena Puntillo, Mariateresa Giglio, Angela Preziosa, Lidia Dalfino in Pain and Therapy (2020)

  10. Article

    Open Access

    A Bilateral Lumbar Multidermatomal Herpes Zoster in an Elderly Woman with Chronic Kidney Disease

    Herpes zoster (HZ) is a painful rash caused by the reactivation of the varicella-zoster virus (VZV) permanently latent within the cranial or dorsal root ganglia. Usually the rash presents in only one side of t...

    Filomena Puntillo, Mariateresa Giglio, Angela Preziosa, Roberta Mele in Pain and Therapy (2020)

  11. Article

    Open Access

    An Ensemble of Psychological and Physical Health Indices Discriminates Between Individuals with Chronic Pain and Healthy Controls with High Reliability: A Machine Learning Study

    Chronic pain (CP) is a complex multidimensional experience severely affecting individuals’ quality of life. Multiple cognitive, affective, emotional, and interpersonal factors play a major role in CP. Furtherm...

    Linda A. Antonucci, Alessandro Taurino, Domenico Laera, Paolo Taurisano in Pain and Therapy (2020)

  12. Article

    Open Access

    Vasopressor-Sparing Action of Methylene Blue in Severe Sepsis and Shock: A Narrative Review

    Shock is a serious acute circulatory failure leading to inadequate oxygen delivery to the cells. Its treatment is mainly based on circulating fluid optimization, and vasopressors to provide an adequate mean ar...

    Filomena Puntillo, Mariateresa Giglio, Alberto Pasqualucci in Advances in Therapy (2020)

  13. Article

    Open Access

    Hemodynamic goal-directed therapy and postoperative kidney injury: an updated meta-analysis with trial sequential analysis

    Perioperative goal-directed therapy (GDT) reduces the risk of renal injury. However, several questions remain unanswered, such as target, kind of patients and surgery, and role of fluids and inotropes. We ther...

    Mariateresa Giglio, Lidia Dalfino, Filomena Puntillo, Nicola Brienza in Critical Care (2019)

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    Book

  15. No Access

    Chapter

    Nerve Entrapment Syndromes

    Entrapment neuropathy is the most frequent mono-neuropathy encountered in clinical practice. It is defined as a pressure-induced injury to a peripheral nerve usually by fibrous bands and ligaments at the level...

    Filomena Puntillo, Laura Bertini in Ultrasound-Guided Peripheral Nerve Blocks (2018)

  16. No Access

    Chapter

    US-Guided Nerve Blocks: Procedure Technique

    The introduction of ultrasound guidance has been a marked advance in the practice of regional anaesthesia, and has gained popularity as an adjunct or alternative to nerve stimulation technique. Ultrasound-guid...

    Filomena Puntillo, Laura Bertini, Mario Bosco in Ultrasound-Guided Peripheral Nerve Blocks (2018)

  17. Article

    Open Access

    P076. Improving patient communication and management by the use of the “Headache Digest”, a pilot study

    Maria Pia Prudenzano, Paola Mogavero, Eva Moretti in The Journal of Headache and Pain (2015)

  18. Article

    Open Access

    Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial

    Candida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.

    Mariateresa Giglio, Giuseppina Caggiano, Lidia Dalfino, Nicola Brienza in Critical Care (2012)

  19. Article

    Open Access

    Haemodynamic goal-directed therapy and postoperative infections: earlier is better. a systematic review and meta-analysis

    Infectious complications are the main causes of postoperative morbidity. The early timing of their promoting factors is the rationale for perioperative strategies attempting to reduce them. Our aim was to dete...

    Lidia Dalfino, Maria T Giglio, Filomena Puntillo, Massimo Marucci in Critical Care (2011)