-
Article
Open AccessIneffectiveness of hemoadsorption in large animals with abdominal sepsis: a randomized controlled porcine study
The use of hemoadsorption (HA) has become popular in the treatment of vasoplegic states associated with massive cytokine release, including septic shock. However, this approach does not seem to be based on rob...
-
Article
Open AccessFGF-23 is a biomarker of RV dysfunction and congestion in patients with HFrEF
There is no biomarker reflecting right ventricular dysfunction in HFrEF patients used in clinical practice. We have aimed to look for a circulating marker of RV dysfunction employing a quantitative proteomic s...
-
Article
Open AccessSepsEast Registry indicates high mortality associated with COVID-19 caused acute respiratory failure in Central-Eastern European intensive care units
The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to charact...
-
Article
Open AccessMetformin treatment is associated with improved outcome in patients with diabetes and advanced heart failure (HFrEF)
The role of metformin (MET) in the treatment of patients with advanced HFrEF and type 2 diabetes mellitus (DM) is not firmly established. We studied the impact of MET on metabolic profile, quality of life (QoL...
-
Article
Open AccessSuccessful treatment of refractory status asthmaticus with omalizumab: a case report
Refractory status asthmaticus is the cause of rare cases of in-hospital death due to acute bronchial asthma. The most severe cases unresponsive to first, second and next line treatment may be fatal despite agg...
-
Article
Open AccessRight versus left ventricular remodeling in heart failure due to chronic volume overload
Mechanisms of right ventricular (RV) dysfunction in heart failure (HF) are poorly understood. RV response to volume overload (VO), a common contributing factor to HF, is rarely studied. The goal was to identif...
-
Chapter
Hemodynamic Monitoring and Optimization in Noncardiac Surgery
Monitoring hemodynamics is one of the basic prerequisites of safety in anesthesia and intensive care. Nowadays, we can choose the appropriate level of hemodynamic monitoring depending on the complexity of the ...
-
Chapter
Pulse Wave Analysis
The cardiac output monitoring devices based on pulse wave analysis (PWA) became a standard of hemodynamic management in many selected patients in critical and perioperative care. They are known as “minimally i...
-
Chapter
Hemodynamic Monitoring and Therapy in Hypovolemic Shock
Hypovolemic shock is a pathologic state of reduced circulating volume leading to decreased venous return, cardiac filling and hence low cardiac output. The human body has several strong regulatory mechanisms t...
-
Article
Open AccessAzithromycin added to hydroxychloroquine for patients admitted to intensive care due to coronavirus disease 2019 (COVID-19)—protocol of randomised controlled trial AZIQUINE-ICU
Novel coronavirus SARS-CoV-2 is known to be susceptible in vitro to exposure to hydroxychloroquine and its effect has been found to be potentiated by azithromycin. We hypothesise that early administration of h...
-
Article
Open AccessEndothelial glycocalyx in acute care surgery – what anaesthesiologists need to know for clinical practice
The endothelial glycocalyx (EG) is the thin sugar-based lining on the apical surface of endothelial cells. It has been linked to the physiological functioning of the microcirculation and has been found to be d...
-
Article
Propofol versus sevoflurane anaesthesia: effect on cognitive decline and event-related potentials
Postoperative cognitive dysfunction (POCD) is diagnosed in up to 30% patients after anaesthesia. The causative role of anaesthetic toxicity remains unclear. Using clinical tests, no clear-cut differences have ...
-
Article
Intensive care medicine in 2050: perioperative critical care
-
Article
Open AccessMolecular differences in susceptibility of the kidney to sepsis-induced kidney injury
Septic acute kidney injury affects 40–50% of all septic patients. Molecular differences between septic patients with and without acute kidney injury (AKI) are only poorly understood. Here, we investigated gene...
-
Article
Comparison of the accuracy of hemoglobin point of care testing using HemoCue and GEM Premier 3000 with automated hematology analyzer in emergency room
The laboratory analysis provides accurate, but time consuming hemoglobin level estimation especially in the emergency setting. The reliability of time-sparing point of care devices (POCT) remains uncertain. We...
-
Article
Open AccessFluid management guided by a continuous non-invasive arterial pressure device is associated with decreased postoperative morbidity after total knee and hip replacement
The use of goal directed fluid protocols in intermediate risk patients undergoing hip or knee replacement was studied in few trials using invasive monitoring. For this reason we have implemented two different ...
-
Article
Continuous non-invasive monitoring improves blood pressure stability in upright position: randomized controlled trial
Intermittent blood pressure (BP) monitoring is the standard-of-care during low and intermediate risk anaesthesia, yet it could lead to delayed recognition of BP fluctuations. Perioperative hypotension is known...
-
Article
Open AccessThe effects of goal-directed fluid therapy based on dynamic parameters on post-surgical outcome: a meta-analysis of randomized controlled trials
Dynamic predictors of fluid responsiveness, namely systolic pressure variation, pulse pressure variation, stroke volume variation and pleth variability index have been shown to be useful to identify in advance...
-
Article
Respiratory induced dynamic variations of stroke volume and its surrogates as predictors of fluid responsiveness: applicability in the early stages of specific critical states
Respiratory induced dynamic variations of stroke volume and its surrogates are very sensitive and specific predictors of fluid responsiveness, but their use as targets for volume management can be limited. In ...
-
Article
Open AccessCost analysis of the stroke volume variation guided perioperative hemodynamic optimization – an economic evaluation of the SVVOPT trial results
Perioperative goal directed therapy (GDT) can substantially improve the outcomes of high risk surgical patients as shown by many clinical studies. However, the approach needs initial investment and can increas...
