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Article
Open AccessDopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo
The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndr...
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Article
Open AccessTransdiagnostic subgroups of cognitive impairment in early affective and psychotic illness
Cognitively impaired and spared patient subgroups were identified in psychosis and depression, and in clinical high-risk for psychosis (CHR). Studies suggest differences in underlying brain structural and func...
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Article
Open AccessSimilarities and differences between multivariate patterns of cognitive and socio-cognitive deficits in schizophrenia, bipolar disorder and related risk
Cognition and social cognition anomalies in patients with bipolar disorder (BD) and schizophrenia (SCZ) have been largely documented, but the degree of overlap between the two disorders remains unclear in this...
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Article
Open AccessThe harmonium model and its unified system view of psychopathology: a validation study by means of a convolutional neural network
The harmonium model (HM) is a recent conceptualization of the unifying view of psychopathology, namely the idea of a general mechanism underpinning all mental disorders (the p factor). According to HM, psychop...
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Article
Open AccessThe impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis
Subtle subjective visual dysfunctions (VisDys) are reported by about 50% of patients with schizophrenia and are suggested to predict psychosis states. Deeper insight into VisDys, particularly in early psychosi...
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Article
Open AccessThe clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study
Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characte...
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Article
Open AccessAssociation between formal thought disorders, neurocognition and functioning in the early stages of psychosis: a systematic review of the last half-century studies
Recent review articles provided an extensive collection of studies covering many aspects of format thought disorders (FTD) among their epidemiology and phenomenology, their neurobiological underpinnings, genet...
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Article
Open AccessPattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis
Continued cannabis use (CCu) is an important predictor for poor long-term outcomes in psychosis and clinically high-risk patients, but no generalizable model has hitherto been tested for its ability to predict...
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Article
Open AccessPre-surgery supportive and goal-oriented strategies are associated with lower post-surgery perceived distress in women diagnosed with breast cancer
Psycho-oncology literature pointed out that individual health outcomes may depend on patients’ propensity to adopt approach or, conversely, avoidant co** strategies. Nevertheless, co** factors associated with...
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Article
Open AccessInvestigating defensive functioning and alexithymia in substance use disorder patients
Substance Use Disorder (SUD) causes a great deal of personal suffering for patients. Recent evidence highlights how defenses and emotion regulation may play a crucial part in the onset and development of this ...
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Article
Open AccessCognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?
In schizophrenia, neurocognitive subtypes can be distinguished based on cognitive performance and they are associated with neuroanatomical alterations. We investigated the existence of cognitive subtypes in sh...
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Article
Open AccessAssociation between age of cannabis initiation and gray matter covariance networks in recent onset psychosis
Cannabis use during adolescence is associated with an increased risk of develo** psychosis. According to a current hypothesis, this results from detrimental effects of early cannabis use on brain maturation ...
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Article
Open AccessMultimodal prognosis of negative symptom severity in individuals at increased risk of develo** psychosis
Negative symptoms occur frequently in individuals at clinical high risk (CHR) for psychosis and contribute to functional impairments. The aim of this study was to predict negative symptom severity in CHR after...
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Article
Open AccessMachine learning-based ability to classify psychosis and early stages of disease through parenting and attachment-related variables is associated with social cognition
Recent views posited that negative parenting and attachment insecurity can be considered as general environmental factors of vulnerability for psychosis, specifically for individuals diagnosed with psychosis (...
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Article
Open AccessA multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis
Two decades of studies suggest that computerized cognitive training (CCT) has an effect on cognitive improvement and the restoration of brain activity. Nevertheless, individual response to CCT remains heteroge...
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Article
The interaction between cannabis use and a CB1-related polygenic co-expression index modulates dorsolateral prefrontal activity during working memory processing
Convergent findings indicate that cannabis use and variation in the cannabinoid CB1 receptor coding gene (CNR1) modulate prefrontal function during working memory (WM). Other results also suggest that cannabis mo...
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Article
Open AccessAn Ensemble of Psychological and Physical Health Indices Discriminates Between Individuals with Chronic Pain and Healthy Controls with High Reliability: A Machine Learning Study
Chronic pain (CP) is a complex multidimensional experience severely affecting individuals’ quality of life. Multiple cognitive, affective, emotional, and interpersonal factors play a major role in CP. Furtherm...
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Article
The interaction between OXTR rs2268493 and perceived maternal care is associated with amygdala–dorsolateral prefrontal effective connectivity during explicit emotion processing
Previous studies have indicated a link between socio-emotional processing and the oxytocin receptor. In this regard, a single nucleotide polymorphism in the oxytocin receptor coding gene (OXTR rs2268493) has been...
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Article
Multivariate classification of schizophrenia and its familial risk based on load-dependent attentional control brain functional connectivity
Patients with schizophrenia (SCZ), as well as their unaffected siblings (SIB), show functional connectivity (FC) alterations during performance of tasks involving attention. As compared with SCZ, these alterat...
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Article
Thalamic connectivity measured with fMRI is associated with a polygenic index predicting thalamo-prefrontal gene co-expression
The functional connectivity between thalamic medio-dorsal nucleus (MD) and cortical regions, especially the dorsolateral prefrontal cortex (DLPFC), is implicated in attentional processing and is anomalous in s...
