5 Result(s)
-
Article
Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation
Tamoxifen (TAM) is commonly used for cell type specific Cre recombinase-induced gene inactivation and in cell fate tracing studies. Inducing a gene knockout by TAM and using non-TAM exposed mice as controls le...
-
Article
Open AccessThe formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes
Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like ...
-
Article
Comparative analysis of 3D culture methods on human HepG2 cells
Human primary hepatocytes represent a gold standard in in vitro liver research. Due to their low availability and high costs alternative liver cell models with comparable morphological and biochemical charact...
-
Article
Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials
RNA interference has become an indispensable research tool to study gene functions in a wide variety of organisms. Because of their high efficacy and specificity, RNA interference-based approaches may also tra...
-
Article
Caffeine reversal of sleep deprivation effects on alertness and mood
This study assessed the ability of high doses of caffeine to reverse changes in alertness and mood produced by prolonged sleep deprivation. Fifty healthy, nonsmoking males between the ages of 18 and 32 served ...
