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Article
Open AccessIn vitro biological assessment of the stability of cigarette smoke aqueous aerosol extracts
Cigarette smoke aqueous aerosol extracts (AqE) have been used for assessing tobacco products, particularly with in vitro models such as oxidative stress and inflammation. These test articles can be generated e...
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Article
Study of MnO2-Graphene Oxide nanocomposites for supercapacitor applications
Graphene oxide (GO)/MnO2 nanocomposites were synthesized by adding KMnO4 in a solution of water and ethanol (3:1), containing 10 mg of GO. Brown precipitates were obtained after a continuous stirring for 1 hr. Th...
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Article
Open AccessReduced biological effect of e-cigarette aerosol compared to cigarette smoke evaluated in vitro using normalized nicotine dose and RNA-seq-based toxicogenomics
Electronic cigarettes (e-cigarettes) use has increased globally and could potentially offer a lower risk alternative to cigarette smoking. Here, we assessed the transcriptional response of a primary 3D airway ...
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Article
Open AccessApplication of dosimetry tools for the assessment of e-cigarette aerosol and cigarette smoke generated on two different in vitro exposure systems
The diluted aerosols from a cigarette (3R4F) and an e-cigarette (Vype ePen) were compared in two commercially available in vitro exposure systems: the Borgwaldt RM20S and Vitrocell VC10. Dosimetry was assessed...
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Article
Open AccessDevelopment of a BALB/c 3T3 neutral red uptake cytotoxicity test using a mainstream cigarette smoke exposure system
Tobacco smoke toxicity has traditionally been assessed using the particulate fraction under submerged culture conditions which omits the vapour phase elements from any subsequent analysis. Therefore, methodolo...
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Article
The temperature–productivity squeeze: constraints on brook trout growth along an Appalachian river continuum
We tested the hypothesis that brook trout growth rates are controlled by a complex interaction of food availability, water temperature, and competitor density. We quantified trout diet, growth, and consumption...
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Article
Open AccessCharacterisation of a Vitrocell® VC 10 in vitrosmoke exposure system using dose tools and biological analysis
The development of whole smoke exposure systems have been driven by the fact that traditional smoke exposure techniques are based on the particulate phase of tobacco smoke and not the complete smoke aerosol. T...
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Article
Open AccessAssessment of cigarette smoke particle deposition within the Vitrocell® exposure module using quartz crystal microbalances
Cigarette smoking is a cause of a variety of serious diseases, and to understand the toxicological impact of tobacco smoke in vitro, whole smoke exposure systems can be used. One of the main challenges of the dif...
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Article
Open AccessIntegrating GPCR-specific information with full text articles
With the continued growth in the volume both of experimental G protein-coupled receptor (GPCR) data and of the related peer-reviewed literature, the ability of GPCR researchers to keep up-to-date is becoming i...
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Article
Open AccessVisualising biological data: a semantic approach to tool and database integration
In the biological sciences, the need to analyse vast amounts of information has become commonplace. Such large-scale analyses often involve drawing together data from a variety of different databases, held rem...
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Chapter and Conference Paper
\(^{\textrm{\small{my}}}\) Grid and UTOPIA: An Integrated Approach to Enacting and Visualising in Silico Experiments in the Life Sciences
In silico experiments have hitherto required ad hoc collections of scripts and programs to process and visualise biological data, consuming substantial amounts of time and effort to build, and leading to tools...
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Article
Caffeine reversal of sleep deprivation effects on alertness and mood
This study assessed the ability of high doses of caffeine to reverse changes in alertness and mood produced by prolonged sleep deprivation. Fifty healthy, nonsmoking males between the ages of 18 and 32 served ...
