6 Result(s)
within
Maria Thomas
Life Sciences
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Article
Open AccessEthanol sensitizes hepatocytes for TGF-β-triggered apoptosis
Alcohol abuse is a global health problem causing a substantial fraction of chronic liver diseases. Abundant TGF-β—a potent pro-fibrogenic cytokine—leads to disease progression. Our aim was to elucidate the cro...
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Article
Open AccessPathobiochemical signatures of cholestatic liver disease in bile duct ligated mice
Disrupted bile secretion leads to liver damage characterized by inflammation, fibrosis, eventually cirrhosis, and hepatocellular cancer. As obstructive cholestasis often progresses insidiously, markers for the...
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Article
Open AccessVirtual pathway explorer (viPEr) and pathway enrichment analysis tool (PEANuT): creating and analyzing focus networks to identify cross-talk between molecules and pathways
Interpreting large-scale studies from microarrays or next-generation sequencing for further experimental testing remains one of the major challenges in quantitative biology. Combining expression with physical ...
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Article
Open AccessTargeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained
DNA methylation and histone 3 lysine 9 (H3K9) methylation are considered as epigenetic marks that can be inherited through cell divisions. To explore the functional consequences and stability of these modifica...
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Article
Open AccessA novel reverse transduction adenoviral array for the functional analysis of shRNA libraries
The identification of novel drug targets by assessing gene functions is most conveniently achieved by high-throughput loss-of-function RNA interference screening. There is a growing need to employ primary cell...
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Chapter
RNA Interference in Haematopoietic and Leukaemic Cells
The haematopoietic system is currently the best characterized mammalian differentiation system. On the one hand, pathologic disturbance of the differentiation programmes results in the development of haemopoie...
