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Article
Open AccessComparing distress of mouse models for liver damage
In order to foster animal welfare as well as high quality of research, many countries regulate by law that the severity of animal experiments must be evaluated and considered when performing biomedical researc...
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Article
Open AccessLiver-specific Repin1 deficiency impairs transient hepatic steatosis in liver regeneration
Transient hepatic steatosis upon liver resection supposes functional relationships between lipid metabolism and liver regeneration. Repin1 has been suggested as candidate gene for obesity and dyslipidemia by r...
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Article
Open AccessPathobiochemical signatures of cholestatic liver disease in bile duct ligated mice
Disrupted bile secretion leads to liver damage characterized by inflammation, fibrosis, eventually cirrhosis, and hepatocellular cancer. As obstructive cholestasis often progresses insidiously, markers for the...
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Article
Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury
Acute liver failure (ALF) is a life threatening disease for which only few treatment options exist. The molecular pathways of disease progression are not well defined, but the death receptor Fas (CD95/Apo-1) a...
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Reference Work Entry In depth
Anatomy and Physiology of the Hepatic Circulation
The liver with its complex functions in biosynthesis, metabolism, clearance, and host defense plays a central role in the physiology of the human body. Hepatic homeostasis is highly dependent on adequate perfu...
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Article
Anti-apoptotic therapeutic approaches in liver diseases: do they really make sense?
A variety of data suggesting apoptotic cell death as a key feature of liver injury stimulated researchers to investigate the therapeutic potential of anti-apoptotic strategies in experimental models. However, ...
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Article
A critical appraisal of the hemodynamic signal driving liver regeneration
Many aspects of the signaling mechanisms involved in the initiation of hepatic regeneration are under current investigation. Nevertheless, the actual mechanisms switching liver regeneration on and off are stil...
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Article
Hepatocellular apoptosis is mediated by TNFα-dependent Fas/FasLigand cytotoxicity in a murine model of acute liver failure
There is increasing evidence that the active contribution of hepatocytes to liver disease is strongly dependent on local cytokine environment. It has been shown in vitro that TNFα can enhance hepatocyte FasLig...
