23 Result(s)

Article

Arterial stiffness and multiple organ damage: a longitudinal study in population

Previous cross-sectional observation identified arterial aging, indexed as pulse-wave velocity (PWV), as a key determinant of the simultaneous multiple organ damage (heart, carotid artery, and kidney). The aim...

Angelo Scuteri, Cristopher H. Morrell… in Aging Clinical and Experimental Research (2020)

Article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 lo...

Dan E Arking, Sara L Pulit, Lia Crotti, Pim van der Harst… in Nature Genetics (2014)

Chapter

Role of Striatal A_2A Receptor Subpopulations in Neurological Disorders

A very significant density of adenosine A_2A receptors (A_2AR) is present in the striatum, where they are preferentially localized postsynaptically in enkephalinergic-GABAergic-medium spiny neurons (enkephalinergic...

Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart, Seema Gulyani… in Adenosine (2013)

Article

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and pla...

Joshua C Bis, Maryam Kavousi, Nora Franceschini, Aaron Isaacs… in Nature Genetics (2011)

Article

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Paul Elliott, Martin Tobin, Cornelia van Duijn and colleagues report a genome-wide association study for pulse pressure and mean arterial pressure, identifying six new loci influencing these two traits.

Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi… in Nature Genetics (2011)

Article

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly di...

Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena… in Nature Genetics (2010)

Article

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

Arne Pfeufer, Aravinda Chakravarti and colleagues from the QTSCD consortium report genetic associations influencing the QT interval duration, a measure of cardiac repolarization which is a risk factor for sudd...

Arne Pfeufer, Serena Sanna, Dan E Arking, Martina Müller, Vesela Gateva… in Nature Genetics (2009)

Article

Variants in MTNR1B influence fasting glucose levels

Gonçalo Abecasis and colleagues report associations with fasting plasma glucose levels in a collection of ten genome–wide association scans from the MAGIC consortium. They find variants in the gene encoding me...

Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena… in Nature Genetics (2009)

Article

Effects of tryptophan deficiency on prepulse inhibition of the acoustic startle in rats

Serotonin (5-HT) plays a key role in the pathophysiology of psychotic disorders, presumably through a modulation of dopamine (DA) transmission. Reduction of 5-HT signaling has been suggested to enhance dopamin...

Marco Bortolato, Roberto Frau, Marco Orrù, Maria Collu… in Psychopharmacology (2008)

Article

Activation of GABA_B receptors reverses spontaneous gating deficits in juvenile DBA/2J mice

Gamma-amino-butyric acid (GABA)_B receptors play a key role in the pathophysiology of psychotic disorders. We previously reported that baclofen, the prototypical GABA_B agonist, elicits antipsychotic-like effects i...

Marco Bortolato, Roberto Frau, Marco Orrù, A. Paola Piras, Mauro Fà… in Psychopharmacology (2007)

Article

The CB receptor agonist WIN 55,212-2 fails to elicit disruption of prepulse inhibition of the startle in Sprague-Dawley rats

A growing evidentiary body indicates cannabinoid exposure is conducive to cognitive impairment and psychotic phenomena in vulnerable individuals. In this respect, recent studies have displayed controversial re...

Marco Bortolato, Gian Nicola Aru, Roberto Frau, Marco Orrù… in Psychopharmacology (2005)

Article

Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine

Since baclofen, the prototypical GABA_B receptor agonist, is known to reduce the activity of dopaminergic mesolimbic neurons, a putative antipsychotic property of this compound has been suggested, but the evidence...

Marco Bortolato, Roberto Frau, Gian Nicola Aru, Marco Orrù… in Psychopharmacology (2004)

Article

The explanation of economic structures

Marco Orrù in Theory and Society (1991)