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Article
Open AccessHuman tissue lead (Pb) levels and amyotrophic lateral sclerosis: a systematic review and meta-analysis of case–control studies
To combine the current scientific literature evidence and elucidate the differences of lead (Pb) bioaccumulation in human tissues by comparing amyotrophic lateral sclerosis (ALS) patients and healthy controls.
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Article
Open AccessA blood DNA methylation biomarker for predicting short-term risk of cardiovascular events
Recent evidence highlights the epidemiological value of blood DNA methylation (DNAm) as surrogate biomarker for exposure to risk factors for non-communicable diseases (NCD). DNAm surrogate of exposures predict...
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Article
Open AccessSpectral characterisation of ventricular intracardiac potentials in human post-ischaemic bipolar electrograms
Abnormal ventricular potentials (AVPs) are frequently referred to as high-frequency deflections in intracardiac electrograms (EGMs). However, no scientific study performed a deep spectral characterisation of A...
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Article
Open AccessSix months of high-dose xylitol in high-risk caries subjects—a 2-year randomised, clinical trial
The hypothesis was that the daily use of a high dose of a xylitol chewing gum for 6 months would reduce the increment of decayed permanent first molar surfaces (ΔD6S) in high-risk schoolchildren after 2 years.
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Article
Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis
The axonal cytoskeleton is a finely organized system, essential for maintaining the integrity of the axon. Axonal degeneration is implicated in the pathogenesis of unremitting disability of multiple sclerosis ...
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Article
An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis
Hepatocarcinogenesis is under polygenic control. We analyzed gene expression patterns of dysplastic liver nodules (DNs) and hepatocellular carcinomas (HCCs) chemically-induced in F344 and BN rats, respectively...
