17 Result(s)

Article

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel Na_V1.5, susceptibility genes remain largely u...

Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang… in Nature Genetics (2022)

Chapter and Conference Paper

A Systems Biology Approach to Decipher Genetic Variants in a Canine Model of Sudden Cardiac Death

Sudden cardiac death (SCD) represents a major public health challenge, accounting for approximately 25% of all cardiac deaths. It refers to an unexpected death from ventricular arrhythmia, occurring in indivi...

Martina Vescio, Lia Crotti, Peter Schwartz… in XV Mediterranean Conference on Medical and… (2020)

Chapter

Specific Cardiovascular Diseases and Competitive Sports Participation: Channelopathies

Long QT Syndrome, Short QT Syndrome, Brugada Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia are inherited primary disorders with the common denominators of a genetic basis and absence of st...

Silvia Castelletti, Lia Crotti in Textbook of Sports and Exercise Cardiology (2020)

Article

Neuroimmune crosstalk in the pathophysiology of hypertension

Hypertension is an important risk factor for cardiovascular morbidity and mortality and for events such as myocardial infarction, stroke, heart failure and chronic kidney disease and is a major determinant of ...

Laura Calvillo, Mariela M. Gironacci, Lia Crotti… in Nature Reviews Cardiology (2019)

Chapter

Genetics of Adult and Fetal Forms of Long QT Syndrome

Long QT syndrome (LQTS) is an inherited cardiac disease characterized by prolongation of QT interval at surface ECG, T-wave abnormalities, and high risk of life-threatening arrhythmias in otherwise healthy you...

Lia Crotti, Alice Ghidoni, Federica Dagradi in Genetic Causes of Cardiac Disease (2019)

Chapter

Long and Short QT Syndromes

The long and short QT syndromes are genetically transmitted arrhythmogenic diseases characterized by an abnormal QTc on the basal ECG and by an increased risk of life-threatening arrhythmias. While in the long...

Lia Crotti, Maria-Christina Kotta, Silvia Castelletti in Channelopathies in Heart Disease (2018)

Article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 lo...

Dan E Arking, Sara L Pulit, Lia Crotti, Pim van der Harst… in Nature Genetics (2014)

Article

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Connie Bezzina, Richard Redon and colleagues show that common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disorder with high risk of sudden cardiac death. The newly discovered l...

Connie R Bezzina, Julien Barc, Yuka Mizusawa, Carol Ann Remme… in Nature Genetics (2013)

Chapter

PREDESTINATION: PRimary vEntricular fibrillation and suDden dEath during a firST myocardIal iNfArcTION: Genetic Basis

Sudden cardiac death (SCD) is the leading cause of death in the age group 20–65 years, in the western world, with an enormous social and economic impact. The majority of the cases of ventricular fibrillation (...

Gaetano M. De Ferrari, Valentina De Regibus… in New Diagnostic, Therapeutic and Organizati… (2013)

Article

Idiopathic Ventricular Fibrillation

Silvia G. Priori, Lia Crotti in Cardiac Electrophysiology Review (1999)