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Article
Open AccessBacteremia from streptococcus constellatus revealing a gastrointestinal stromal tumor
Pyogenic Liver Abscesses (PLA) are the most common type of visceral abscess. They generally develop in a context of biliary disease or hematogenous seeding, but a complete diagnostic work-up is always required...
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Article
Open AccessGlucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes
High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) i...
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Article
Dilated hypertrophic phenotype of the carotid artery is associated with accelerated age-associated central arterial stiffening
Hypertrophic carotid geometric phenotypes (h-CGP) are predictors of incident cardiovascular disease (CVD). While arterial aging is hypothesized as a contributor to this associated risk, the association of CGPs...
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Article
Subclinical HMOD in Hypertension: Brain Imaging and Cognitive Function
Latest European Societies of Hypertension and Cardiology (ESH/ESC) have acknowledged that brain represent a relevant target for hypertension mediated organ damage (HMOD). In fact, brain damage can be the only ...
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Article
Open AccessClusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study
The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on...
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Article
Open AccessRole of imaging in rare COVID-19 vaccine multiorgan complications
As of September 18th, 2021, global casualties due to COVID-19 infections approach 200 million, several COVID-19 vaccines have been authorized to prevent COVID-19 infection and help mitigate the spread of the v...
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Article
The appropriateness of antiplatelet and anticoagulant drug prescriptions in hospitalized patients in an internal medicine ward
Polypharmacy increases the risk of potentially inappropriate prescribing. STOPP&START criteria identify a group of drugs representing inappropriate medication and a group of drugs representing potential prescr...
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Article
Is Arterial Stiffness a Determinant of Hypotension?
Previous observation identified both hypotension and arterial aging, indexed as Pulse Wave Velocity (PWV), as significant determinants of cognitive decline in older subjects.
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Article
Arterial stiffness and multiple organ damage: a longitudinal study in population
Previous cross-sectional observation identified arterial aging, indexed as pulse-wave velocity (PWV), as a key determinant of the simultaneous multiple organ damage (heart, carotid artery, and kidney). The aim...
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Article
Common Carotid Artery Calcification Impacts on Cognitive Function in Older Patients
Cognitive impairment and dementia represent an emerging health problem. Cardiovascular (CV) risk factors contribute to cognitive impairment.
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Article
Open Access3.3 Role of Arterial Stiffness and Blood Pressure Variability in the Definition of Shats (Systemic Hemodynamic Atherothrombotic Syndrome)
CV risk exponentially increases as the number of damaged organs increases The Systemic Hemodynamic Atherosclerotic Syndrome (SHATS) represents a novel conceptualization of the CV continuum focusing on simultan...
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Article
Frequency of early vascular aging and associated risk factors among an adult population in Latin America: the OPTIMO study
The main objective was to estimate the frequency of early vascular aging (EVA) in a sample of subjects from Latin America, with emphasis in young adults. We included 1416 subjects from 12 countries in Latin Am...
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Article
Open AccessHow to Improve Effectiveness and Adherence to Antihypertensive Drug Therapy: Central Role of Dihydropyridinic Calcium Channel Blockers in Hypertension
Essential hypertension is a complex clinical condition, characterized by multiple and concomitant abnormal activation of different regulatory and contra-regulatory pathophysiological mechanisms, leading to sus...
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Article
Can Antihypertensive Medication Interfere with the Vicious Cycle Between Hypertension and Vascular Calcification?
Vascular calcification is a phenomenon of disturbed calcium deposition, as part of the calcium that is supposed to be deposited to our bones, is lodged to our vessels. There are two forms of vascular calcifica...
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Article
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Kathryn Lunetta and colleagues report a meta-analysis of 22 genome-wide association studies for age at menopause. They identify 13 loci newly associated with age at natural menopause, including several candida...
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Article
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque
Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and pla...
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Article
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Ken Ong and colleagues report meta-analysis of 32 genome-wide association studies for age at menarche. They identify 30 loci newly associated with age at menarche, including four that were previously associate...
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Article
Biological, clinical and population relevance of 95 loci for blood lipids
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CA...
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Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Nat. Genet. 42, 105–116 (2010); published online 17 January 2010; corrected after print 26 March 2010 In the version of this article initially published, there were several errors in the author affiliations. T...
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Article
Opioids for the Treatment of Chronic Non-Cancer Pain in Older People
Chronic pain occurs in 45–85% of the geriatric population and the need to treat chronic pain is growing substantially. Unfortunately, treatment for chronic pain is not always correctly targeted, which leads to...
