10 Result(s)
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Article
Advances in molecular probe-based labeling tools and their application to multiscale multimodal correlated microscopies
The need to determine the precise subcellular distribution of specific proteins and macromolecular complexes in cells and tissues has been the major driving force behind the development of new molecular-geneti...
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Article
Open AccessDRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma
Glaucoma is the leading cause of irreversible blindness and is characterized by slow and progressive degeneration of the optic nerve head axons and retinal ganglion cell (RGC), leading to loss of visual functi...
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Article
Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death
Evidence indicates that nitrosative stress and mitochondrial dysfunction participate in the pathogenesis of Alzheimer’s disease (AD). Amyloid beta (Aβ) and peroxynitrite induce mitochondrial fragmentation and neu...
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Article
Open AccessInhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes
Oxidative stress contributes to dysfunction of glial cells in the optic nerve head (ONH). However, the biological basis of the precise functional role of mitochondria in this dysfunction is not fully understoo...
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Article
Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity
Optic atrophy 1 ( OPA1 ) mutations cause dominant optic atrophy (DOA) with retinal ganglion cell (RGC) and optic nerve degeneration. The mechanism for the selectiv...
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Article
Open AccessA new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics
Glutamate excitotoxicity leads to fragmented mitochondria in neurodegenerative diseases, mediated by nitric oxide and S-nitrosylation of dynamin-related protein 1, a mitochondrial outer membrane fission protein.
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Article
Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure
Although the identification of specific genes that regulate apoptosis has been a topic of intense study, little is known of the role that background genetic variance plays in modulating cell death. Using germ ...
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Article
Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity
In apoptosis, Bcl-2-family proteins regulate the barrier function of the mitochondrial outer membrane (MOM), controlling the release of proapoptotic proteins from the intermembrane space into the cytoplasm. Th...
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Morphological Adaptation of the Peptidergic Innervation to Chronic Hypoxia in the Rat Carotid Body
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Article
Electron Tomography of Mitochondria from Brown Adipocytes Reveals Crista Junctions
Electron microscope tomography was used to examine the membrane topology of brown adipose tissue (BAT) mitochondria prepared by cryofixation or chemical fixation techniques. These mitochondria contain an uncou...
