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Article
Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells
Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of...
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Article
Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure
Although the identification of specific genes that regulate apoptosis has been a topic of intense study, little is known of the role that background genetic variance plays in modulating cell death. Using germ ...
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Article
Molecular requirements for doxorubicin-mediated death in murine oocytes
We previously published evidence that oocytes exposed to doxorubicin (DXR), a widely used chemotherapeutic agent, rapidly undergo morphological and biochemical changes via discrete effector signaling pathways ...
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Article
Erratum: Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring
Nature Med. 8, 901–902 (2002). Page 902, information was omitted from the affiliation listing. A footnote should have been included referring to authors F. Paris and G.I. Perez stating that these two authors c...
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Article
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function
It is well established that programmed cell death claims up to two-thirds of the oocytes produced during gametogenesis in the develo** fetal ovaries. However, the mechanisms underlying prenatal germ cell los...
