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  1. Article

    Open Access

    Mcl-1 is a key regulator of the ovarian reserve

    A majority of ovarian follicles are lost to natural death, but the disruption of factors involved in maintenance of the oocyte pool results in a further untimely follicular depletion known as premature ovarian...

    S Omari, M Waters, T Naranian, K Kim, A L Perumalsamy, M Chi… in Cell Death & Disease (2015)

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  2. No Access

    Article

    Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression

    BLM is a DNA helicase important for the restart of stalled replication forks and for homologous recombination (HR) repair. Mutations of BLM lead to Bloom Syndrome, a rare autosomal recessive disorder characterize...

    S El Ghamrasni, R Cardoso, M J Halaby, D Zeegers, S Harding, R Kumareswaran… in Oncogene (2015)

  3. Article

    Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia

    We have previously reported that matador/Bcl-2 ovarian killer (Mtd/Bok), a proapoptotic member of the Bcl-2 family, regulates human trophoblast apoptosis and that its levels are elevated in severe preeclamptic...

    J E Ray, J Garcia, A Jurisicova, I Caniggia in Cell Death & Differentiation (2010)

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  4. No Access

    Article

    Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells

    Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of...

    Y. Takai, T. Matikainen, A. Jurisicova, M. R. Kim, A. M. Trbovich, E. Fujita… in Apoptosis (2007)

  5. Article

    Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure

    Although the identification of specific genes that regulate apoptosis has been a topic of intense study, little is known of the role that background genetic variance plays in modulating cell death. Using germ ...

    G I Perez, B M Acton, A Jurisicova, G A Perkins, A White… in Cell Death & Differentiation (2007)

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  6. Article

    Molecular requirements for doxorubicin-mediated death in murine oocytes

    We previously published evidence that oocytes exposed to doxorubicin (DXR), a widely used chemotherapeutic agent, rapidly undergo morphological and biochemical changes via discrete effector signaling pathways ...

    A Jurisicova, H-J Lee, S G D'Estaing, J Tilly, G I Perez in Cell Death & Differentiation (2006)

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  7. Article

    A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia

    Pre-eclampsia is a serious disorder of human pregnancy, characterized by decreased utero-placental perfusion and increased trophoblast cell death. Presently, the mechanisms regulating trophoblast cell death in...

    N Soleymanlou, Y Wu, J X Wang, T Todros, F Ietta… in Cell Death & Differentiation (2005)

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