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Open AccessDRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma
Glaucoma is the leading cause of irreversible blindness and is characterized by slow and progressive degeneration of the optic nerve head axons and retinal ganglion cell (RGC), leading to loss of visual functi...
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Open AccessInhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes
Oxidative stress contributes to dysfunction of glial cells in the optic nerve head (ONH). However, the biological basis of the precise functional role of mitochondria in this dysfunction is not fully understoo...
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Open AccessA new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics
Glutamate excitotoxicity leads to fragmented mitochondria in neurodegenerative diseases, mediated by nitric oxide and S-nitrosylation of dynamin-related protein 1, a mitochondrial outer membrane fission protein.
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Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons
Mitochondrial dysfunction is an underpinning event in many neurodegenerative disorders. Less clear, however, is how mitochondria become injured during neuronal demise. Nitric oxide (NO) evokes rapid mitochondr...
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Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure
Although the identification of specific genes that regulate apoptosis has been a topic of intense study, little is known of the role that background genetic variance plays in modulating cell death. Using germ ...
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Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity
In apoptosis, Bcl-2-family proteins regulate the barrier function of the mitochondrial outer membrane (MOM), controlling the release of proapoptotic proteins from the intermembrane space into the cytoplasm. Th...
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Reference Work Entry In depth
4.2 Mitochondrial Architecture and Heterogeneity
Brain mitochondria are heterogeneous in structure, enzyme complement, energy metabolism, motility, and compartmentation. In recent years, the detailed three-dimensional structure of these organelles has been p...
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Article
Electron Tomography of Mitochondria from Brown Adipocytes Reveals Crista Junctions
Electron microscope tomography was used to examine the membrane topology of brown adipose tissue (BAT) mitochondria prepared by cryofixation or chemical fixation techniques. These mitochondria contain an uncou...
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Article
Oscillating real vectors in Coulomb-bound electron fields
This study is based on relativity and Maxwell’s and Dirao’s equations, without any amendments or added hypothesis. Dirac’s electron equations are used in a tensor form mathematically identical with Whittaker’s...